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GPCR

NameD(3) dopamine receptor
SpeciesHomo sapiens (Human)
GeneDRD3
Synonymdopaminergic receptor D3
D3R
D3 receptor
dopamine D3 receptor
DiseaseUnspecified
Emesis; Gastric motility disorder
Female sexual dysfunction
Male sexual disorders
Psychotic disorders
[ Show all ]
Length400
Amino acid sequenceMASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProtP35462
Protein Data Bank3pbl
GPCR-HGmod modelP35462
3D structure modelThis structure is from PDB ID 3pbl.
BioLiPBL0191566, BL0191567
Therapeutic Target DatabaseT02551
ChEMBLCHEMBL234
IUPHAR216
DrugBankBE0000581

Ligand

Name7-OH-DPAT
Molecular formulaC16H25NO
IUPAC name7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol
Molecular weight247.382
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP4.1
Synonyms(+/-)-7-hydroxy-2-(N,N-di-n-propylamino)tetralin
7-(Dipropylamino)-5,6,7,8-tetrahydro-2-naphthalenol
BDBM50020222
CHEMBL285755
I14-4633
[ Show all ]
Inchi KeyBLYMJBIZMIGWFK-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H25NO/c1-3-9-17(10-4-2)15-7-5-13-6-8-16(18)12-14(13)11-15/h6,8,12,15,18H,3-5,7,9-11H2,1-2H3
PubChem CID1219
ChEMBLCHEMBL285755
IUPHAR3296, 950
BindingDB50020222
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC500.531 nMPMID18410082BindingDB,ChEMBL
EC500.95 nMPMID23018094BindingDB
Emax45.3 %PMID18410082ChEMBL
Kd0.27 nMPMID7759603IUPHAR
Ki0.39 nMPMID7756621PDSP
Ki1.4 nM, Bioorg. Med. Chem. Lett., (1997) 7:21:2759BindingDB,ChEMBL
Ki1.49 nMPMID27035329ChEMBL
Ki1.5 nMPMID27035329BindingDB
Ki1.58 nMPMID10611634PDSP,BindingDB
Ki1.6 nMPMID8301582PDSP,BindingDB
Ki1.75 nMPMID27035329ChEMBL
Ki1.8 nMPMID27035329BindingDB
Ki2.1 nMPMID7756621PDSP
Ki2.19 nMPMID10832613PDSP,BindingDB
Ki2.35 nMPMID20146482BindingDB,ChEMBL
Ki2.4 nMPMID9067310PDSP,BindingDB
Ki2.9 nMPMID7990123BindingDB,ChEMBL
Ki3.02 nMPMID10832613PDSP
Ki3.6 nMPMID18834111BindingDB,ChEMBL
Ki3.98 - 79.4 nMPMID8301582, PMID7756621, PMID7907989, PMID7576010, PMID7990123IUPHAR
Ki4.37 nMPMID10832613PDSP,BindingDB
Ki6.9 nMPMID23018094BindingDB
Ki55.6 nMPMID9067310PDSP,BindingDB

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