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GPCR

Name	Prostaglandin F2-alpha receptor
Species	Homo sapiens (Human)
Gene	PTGFR
Synonym	Prostanoid FP receptor prostaglandin F2-alpha receptor prostaglandin F receptor (FP) prostaglandin F receptor PGF2-alpha receptor PGF2 alpha receptor PGF receptor PF2AR FP receptor [ Show all ]
Disease	Glaucoma Ocular disease Renal cancer Dysmenorrhea Alzheimer disease Aborting pregnancy Open-angle glaucoma; Ocular hypertension [ Show all ]
Length	359
Amino acid sequence	MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
UniProt	P43088
Protein Data Bank	N/A
GPCR-HGmod model	P43088
3D structure model	This predicted structure model is from GPCR-EXP P43088.
BioLiP	N/A
Therapeutic Target Database	T75797
ChEMBL	CHEMBL1987
IUPHAR	344
DrugBank	BE0000610

Ligand

Name	dinoprost
Molecular formula	C20H34O5
IUPAC name	(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid
Molecular weight	354.487
Hydrogen bond acceptor	5
Hydrogen bond donor	4
XlogP	2.7
Synonyms	DSSTox_RID_76800 HMS2089F11 (5Z,13E,15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dien-1-oic acid LMFA03010002 (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(E)-(3S)-3-hydroxy-1-octenyl}-cyclopentyl]-5-heptenoic acid P1885 PGF2.alpha. 9a,11a-PGF2 Prostaglandin F2 B7IN85G1HY Prostaglandin F2\|A CAS-551-11-1 SR-01000721847 CS-4232 U-14583 Dinoprost [USAN:INN:BAN:JAN] Enzaprost F (+)-Prostaglandin F2a HSDB 3315 (5Z,9alpha,11alpha,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dienoate NCGC00160385-01 23518-25-4 PGF-2alpha 7-(3,5-Dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-5-heptenoic acid Prosmon (TN) 9S,11R,15S-trihydroxy-5Z,13E-prostadienoic acid Prostaglandin F2-alpha, racemic mixt. BRN 2225571 Prostin F2-alpha Cerviprost SR-01000946457 D00HTY ZINC3830709 Dinoprostum DSSTox_CID_2946 HMS1791K16 (+-)-PGF2alpha l-PGF2-alpha (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)cyclopentyl)hept-5-enoic acid NCGC00160385-05 5-HEPTENOIC ACID, 7-(3,5-DIHYDROXY-2-(3-HYDROXY-1-OCTENYL)CYCLOPENTYL)-, dl- PGF2-alpha 9,11,15-Trihydroxyprosta-5,13-dien-1-oic acid Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9alpha,11alpha,13E,15S)- amoglandin prostaglandin F2alpha C00639 PXGPLTODNUVGFL-YNNPMVKQSA-N CHEMBL815 U 14583 DTXSID9022946 HMS3402K16 (5Z,9alpha,11alpha,13E,15S)-9,11,15-Trihydroxyprosta-3,13-dien-1-oic acid LS-125835 13535-33-6 panacelan 551-11-1 PGF2a 9alpha,11alpha-PGF2 Prostaglandin F2 alpha BDBM50035622 Prostarmon F CCG-208257 SR-01000721847-2 cyclosin UNII-B7IN85G1HY Dinoprosta GTPL1884 (+)-Prostaglandin F2alpha HY-12956 (5z,9alpha,11alpha,13e,15s)-9,11,15-trihydroxyprosta-5,13-dienoic acid NCGC00160385-02 5-Heptenoic acid, 7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-, (+-)- PGF2 7-[3,5-Dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl]-5-heptenoic acid Prosta-10,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9.alpha.,11.alpha.,13E,15S) AC1NQWY5 Prostaglandin F2.alpha. BRN 4153898 Prostin F2alpha CHEBI:15553 SR-01000946457-1 Dinoprostum [INN-Latin] DSSTox_GSID_22946 HMS1989K16 (5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate l-Prostaglandin F2-alpha (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid NCGC00160385-06 5-Heptenoic acid, 7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-, l- PGF2-alpha racemic mixt. 99437-94-2 Prostaglandin F(sub 2a) AN-796 Prostaglandin F2alpha, dl- C20H34O5 SCHEMBL24292 CP0104 U-14,583 Dinoprost (JP17/USAN/INN) Enzaprost ( )-Prostaglandin F2alpha HMS3648N11 (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oic acid MolPort-005-940-967 PDSP2_000079 62P015 PGF2alpha 9alpha,11beta-PGF2 Prostaglandin F2-alpha BML1-F08 Prostin F 2 alpha CCRIS 4253 SR-01000721847-4 D00081 Y0222 Dinoprosta [INN-Spanish] dl-Prostaglandin F2-alpha HMS1361K16 (+-)-PGF2-alpha IDI1_033964 (E,Z)-(1R,2R,3R,5S)-7-(3,5-Dihydroxy-2-((3S)-(3-hydroxy-1-octenyl))cyclopentyl)-5-heptenoic acid NCGC00160385-04 5-Heptenoic acid, 7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-, (1R-(1alpha(Z),2beta(S*,E),3alpha,5alpha))- PGF2 alpha 9,11,15-Trihydroxy-(5Z,9a,11a,13E,15S)-prosta-5,13-dien-1-oic acid Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9-alpha,11-alpha,13E,15S)-(+-)- (9CI) AKOS030526160 Prostaglandin F2a BSPBio_001494 Protamodin Tox21_111777 DB12789 [ Show all ]
Inchi Key	PXGPLTODNUVGFL-YNNPMVKQSA-N
Inchi ID	InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1
PubChem CID	5280363
ChEMBL	CHEMBL815
IUPHAR	1884
BindingDB	50035622
DrugBank	DB12789
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	24.5 nM	PMID15357985	BindingDB,ChEMBL
EC50	79.0 nM	PMID10915040	BindingDB,ChEMBL
IC50	2.5 nM	PMID10915040	BindingDB,ChEMBL
IC50	3.0 nM	PMID11708917	BindingDB,ChEMBL
IC50	7.0 nM	PMID10715159	BindingDB,ChEMBL
IC50	43.0 nM	PMID2909739	BindingDB,ChEMBL
Ki	3.16228 - 12.5893 nM	PMID16604093, PMID10634944, PMID12519077	IUPHAR
Ki	119.0 nM	PMID10978187	BindingDB,ChEMBL
Response	92.0 %	PMID15357985	ChEMBL

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