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GPCR

NameD(3) dopamine receptor
SpeciesRattus norvegicus (Rat)
GeneDrd3
SynonymD3 receptor
D3R
Dopamine D3 receptor
dopaminergic receptor D3
DiseaseN/A for non-human GPCRs
Length446
Amino acid sequenceMAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
UniProtP19020
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3138
IUPHAR216
DrugBankN/A

Ligand

Name7-OH-DPAT
Molecular formulaC16H25NO
IUPAC name7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol
Molecular weight247.382
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP4.1
SynonymsSCHEMBL623950
(+)-7-(Dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol hydrobromide
2-Naphthalenol,7-(dipropylamino)-5,6,7,8-tetrahydro-
7-hydroxy-2-(dipropylamino)tetralin
BRD-A18795974-004-02-4
[ Show all ]
Inchi KeyBLYMJBIZMIGWFK-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H25NO/c1-3-9-17(10-4-2)15-7-5-13-6-8-16(18)12-14(13)11-15/h6,8,12,15,18H,3-5,7,9-11H2,1-2H3
PubChem CID1219
ChEMBLCHEMBL285755
IUPHAR950, 3296
BindingDB50020222
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC501.11 nMMed Chem Res, (2004) 13:1:25ChEMBL
IC501.25 nMMed Chem Res, (2004) 13:1:25ChEMBL
Kd0.67 nMPMID8277513BindingDB,ChEMBL
Kd0.794 nMPMID1518841IUPHAR
Ki1.18 nMPMID8098771ChEMBL
Ki1.2 nMPMID8098771BindingDB
Ki1.3 nMPMID10327430BindingDB
Ki2.35 nMPMID18410082BindingDB,ChEMBL
Ki2.9 nMPMID8230102, PMID8098771BindingDB,ChEMBL
Ki3.86 nMPMID10327430BindingDB
Ki6.19 nMPMID20605099, PMID19427222, PMID19053758BindingDB,ChEMBL

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