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GPCR

NameNeuropeptide Y receptor type 1
SpeciesHomo sapiens (Human)
GeneNPY1R
Synonymneuropeptide Y receptor type 1
NPY-Y1 receptor
NPY1-R
FC5
Y1 receptor
[ Show all ]
DiseaseHypertension; Obesity; Heart disease
Obesity
Eating disorders reduction in food intake obesity anxiety
Eating disorders reduction in food intake
Eating disorder
[ Show all ]
Length384
Amino acid sequenceMNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
UniProtP25929
Protein Data Bank5zbh
GPCR-HGmod modelP25929
3D structure modelThis structure is from PDB ID 5zbh.
BioLiPBL0411971
Therapeutic Target DatabaseT89213
ChEMBLCHEMBL4777
IUPHAR305
DrugBankN/A

Ligand

NameSMR000264080
Molecular formulaC23H18ClNO3
IUPAC name[2-oxo-2-(2-phenylanilino)ethyl] (E)-3-(4-chlorophenyl)prop-2-enoate
Molecular weight391.851
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP5.4
SynonymsAC1M7PPI
CHEMBL1335124
MLS000409048
(E)-3-(4-chlorophenyl)acrylic acid [2-keto-2-(2-phenylanilino)ethyl] ester
BDBM42557
[ Show all ]
Inchi KeyBMABHLCCGUBBJN-NTCAYCPXSA-N
Inchi IDInChI=1S/C23H18ClNO3/c24-19-13-10-17(11-14-19)12-15-23(27)28-16-22(26)25-21-9-5-4-8-20(21)18-6-2-1-3-7-18/h1-15H,16H2,(H,25,26)/b15-12+
PubChem CID2446403
ChEMBLCHEMBL1335124
IUPHARN/A
BindingDB42557
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC506127.0 nM, PubChem BioAssay data setBindingDB,ChEMBL

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