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Name | Neuropeptide Y receptor type 2 |
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Species | Homo sapiens (Human) |
Gene | NPY2R |
Synonym | NPY2-R NPY-Y2 receptor neuropeptide Y receptor type 2 Y2 receptor |
Disease | Diabetes Metabolic disorders Obesity |
Length | 381 |
Amino acid sequence | MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV |
UniProt | P49146 |
Protein Data Bank | N/A |
GPCR-HGmod model | P49146 |
3D structure model | This predicted structure model is from GPCR-EXP P49146. |
BioLiP | N/A |
Therapeutic Target Database | T10670 |
ChEMBL | CHEMBL4018 |
IUPHAR | 306 |
DrugBank | BE0002419 |
Name | MLS000032393 |
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Molecular formula | C26H26N6O3 |
IUPAC name | 3-[[[1-(furan-2-ylmethyl)tetrazol-5-yl]methyl-[(2-methoxyphenyl)methyl]amino]methyl]-6-methyl-1H-quinolin-2-one |
Molecular weight | 470.533 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 1 |
XlogP | 2.9 |
Synonyms | 3-[[[1-(furan-2-ylmethyl)tetrazol-5-yl]methyl-[(2-methoxyphenyl)methyl]amino]methyl]-6-methyl-1H-quinolin-2-one REGID_for_CID_647823 AC1LDGR8 HMS2309I23 3-[[[1-(2-furfuryl)tetrazol-5-yl]methyl-o-anisyl-amino]methyl]-6-methyl-carbostyril [ Show all ] |
Inchi Key | BMDSAZDIDMDPRU-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C26H26N6O3/c1-18-9-10-23-20(12-18)13-21(26(33)27-23)15-31(14-19-6-3-4-8-24(19)34-2)17-25-28-29-30-32(25)16-22-7-5-11-35-22/h3-13H,14-17H2,1-2H3,(H,27,33) |
PubChem CID | 647823 |
ChEMBL | CHEMBL1608455 |
IUPHAR | N/A |
BindingDB | 42408 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | <35000.0 nM | , PubChem BioAssay data set | BindingDB,ChEMBL |
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