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Name | Muscarinic acetylcholine receptor M3 |
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Species | Homo sapiens (Human) |
Gene | CHRM3 |
Synonym | cholinergic receptor cholinergic receptor, muscarinic 3 cholinergic receptor, muscarinic 3, cardiac Chrm-3 HM4 [ Show all ] |
Disease | Urinary incontinence Overactive bladder Overactive bladder disorder Postoperative nausea and vomiting Respiratory disease [ Show all ] |
Length | 590 |
Amino acid sequence | MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL |
UniProt | P20309 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | T67684 |
ChEMBL | CHEMBL245 |
IUPHAR | 15 |
DrugBank | BE0000045 |
Name | pilocarpine |
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Molecular formula | C11H16N2O2 |
IUPAC name | (3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one |
Molecular weight | 208.261 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 0 |
XlogP | 1.1 |
Synonyms | SR-01000075339-11 ZINC75008 Lopac0_000950 (3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one Miocarpine (TN) [ Show all ] |
Inchi Key | QCHFTSOMWOSFHM-WPRPVWTQSA-N |
Inchi ID | InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1 |
PubChem CID | 5910 |
ChEMBL | CHEMBL550 |
IUPHAR | 305 |
BindingDB | 50008072 |
DrugBank | DB01085 |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
N/A | N/A | DrugBank | |
Efficacy | 76.5 % | PMID25765911 | ChEMBL |
Ki | 7943.28 nM | PMID9224827 | IUPHAR |
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