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GPCR

NameP2Y purinoceptor 1
SpeciesRattus norvegicus (Rat)
GeneP2ry1
SynonymATP receptor
purinergic receptor P2Y
Purinergic receptor
platelet ADP receptor
P2Y1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length373
Amino acid sequenceMTEVPWSAVPNGTDAAFLAGLGSLWGNSTIASTAAVSSSFRCALIKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDVMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAIYVSVLVWLIVVVAISPILFYSGTGIRKNKTVTCYDSTSDEYLRSYFIYSMCTTVAMFCIPLVLILGCYGLIVRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPEMCDFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEEMTLNILSEFKQNGDTSL
UniProtP49651
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2497
IUPHARN/A
DrugBankN/A

Ligand

NameAp3A
Molecular formulaC20H27N10O16P3
IUPAC namebis[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] hydrogen phosphate
Molecular weight756.411
Hydrogen bond acceptor24
Hydrogen bond donor9
XlogP-7.2
SynonymsAdenosine(3)triphosphate adenosine
C06197
P(1),P(3)-bis(5''-adenosyl) trihydrogen triphosphate
A(5')p3(5')A
CHEMBL407938
[ Show all ]
Inchi KeyQCICUPZZLIQAPA-XPWFQUROSA-N
Inchi IDInChI=1S/C20H27N10O16P3/c21-15-9-17(25-3-23-15)29(5-27-9)19-13(33)11(31)7(43-19)1-41-47(35,36)45-49(39,40)46-48(37,38)42-2-8-12(32)14(34)20(44-8)30-6-28-10-16(22)24-4-26-18(10)30/h3-8,11-14,19-20,31-34H,1-2H2,(H,35,36)(H,37,38)(H,39,40)(H2,21,23,25)(H2,22,24,26)/t7-,8-,11-,12-,13-,14-,19-,20-/m1/s1
PubChem CID165381
ChEMBLCHEMBL407938
IUPHARN/A
BindingDB50184368
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC5060.0 nMPMID16539385BindingDB,ChEMBL

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