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GPCR

NameType-1 angiotensin II receptor
SpeciesCavia porcellus (Guinea pig)
GeneAGTR1
SynonymAngiotensin II type-1 receptor
AT1
DiseaseN/A for non-human GPCRs
Length359
Amino acid sequenceMILNSSTEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADICFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCVIIWLMAGLASLPAVIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFMFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIHDCKISDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSTLSTKMSTLSYRPSDNVSSSAKKPVQCFEVE
UniProtQ9WV26
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1671613
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL428711
Molecular formulaC26H27N5O
IUPAC name2-ethyl-4-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methoxy]-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine
Molecular weight425.536
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP5.8
SynonymsBDBM50047127
2-Ethyl-4-[[[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]oxy]-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine
2-Ethyl-4-[2''-(1H-tetrazol-5-yl)-biphenyl-4-ylmethoxy]-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine
Inchi KeyQEPKKBADCQMSFB-UHFFFAOYSA-N
Inchi IDInChI=1S/C26H27N5O/c1-2-20-16-25(23-10-4-3-5-11-24(23)27-20)32-17-18-12-14-19(15-13-18)21-8-6-7-9-22(21)26-28-30-31-29-26/h6-9,12-16H,2-5,10-11,17H2,1H3,(H,28,29,30,31)
PubChem CID15171385
ChEMBLCHEMBL428711
IUPHARN/A
BindingDB50047127
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC5025.0 nMPMID8487261BindingDB,ChEMBL

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