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GPCR

NameG-protein coupled receptor 35
SpeciesHomo sapiens (Human)
GeneGPR35
SynonymG-protein coupled receptor 3
GPR35
KYNA receptor
Kynurenic acid receptor
DiseaseN/A
Length309
Amino acid sequenceMNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
UniProtQ9HC97
Protein Data BankN/A
GPCR-HGmod modelQ9HC97
3D structure modelThis predicted structure model is from GPCR-EXP Q9HC97.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1293267
IUPHAR102
DrugBankBE0005562

Ligand

NameCHEMBL2392149
Molecular formulaC17H11NO5
IUPAC name8-benzamido-4-oxochromene-2-carboxylic acid
Molecular weight309.277
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP2.1
SynonymsBDBM50436034
Inchi KeyQEXKQEDQVPOXOC-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H11NO5/c19-13-9-14(17(21)22)23-15-11(13)7-4-8-12(15)18-16(20)10-5-2-1-3-6-10/h1-9H,(H,18,20)(H,21,22)
PubChem CID71735031
ChEMBLCHEMBL2392149
IUPHARN/A
BindingDB50436034
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC504910.0 nMPMID23713606, PMID23888932BindingDB,ChEMBL
Emax107.0 %PMID23713606ChEMBL
Ki3290.0 nMPMID23888932BindingDB,ChEMBL

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