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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Pyroglutamylated RF-amide peptide receptor
Species	Homo sapiens (Human)
Gene	QRFPR
Synonym	QRFP receptor peptide p518 receptor Orexigenic neuropeptide QRFP receptor GPR103 G-protein coupled receptor 103 G protein-coupled receptor 103 AQ27 SP9155 [ Show all ]
Disease	N/A
Length	431
Amino acid sequence	MQALNITPEQFSRLLRDHNLTREQFIALYRLRPLVYTPELPGRAKLALVLTGVLIFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVAVIVGSPMWHVQQLEIKYDFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKIGYELWIKKRVGDGSVLRTIHGKEMSKIARKKKRAVIMMVTVVALFAVCWAPFHVVHMMIEYSNFEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSPAQRHGNSGITMMRKKAKFSLRENPVEETKGEAFSDGNIEVKLCEQTEEKKKLKRHLALFRSELAENSPLDSGH
UniProt	Q96P65
Protein Data Bank	N/A
GPCR-HGmod model	Q96P65
3D structure model	This predicted structure model is from GPCR-EXP Q96P65.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5852
IUPHAR	333
DrugBank	N/A

Ligand

Name	CHEMBL3287830
Molecular formula	C20H24N2O2S
IUPAC name	N'-[3-(cyclopentylsulfinylmethyl)-4-methoxyphenyl]benzenecarboximidamide
Molecular weight	356.484
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	2.8
Synonyms	BDBM50020025
Inchi Key	QHFZIPSASAAIHW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H24N2O2S/c1-24-19-12-11-17(22-20(21)15-7-3-2-4-8-15)13-16(19)14-25(23)18-9-5-6-10-18/h2-4,7-8,11-13,18H,5-6,9-10,14H2,1H3,(H2,21,22)
PubChem CID	90644588
ChEMBL	CHEMBL3287830
IUPHAR	N/A
BindingDB	50020025
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<39810.7 nM	PMID24900874	ChEMBL
IC50	>39811.0 nM	PMID24900874	BindingDB

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