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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Histamine H4 receptor
Species	Homo sapiens (Human)
Gene	HRH4
Synonym	Pfi-013 SP9144 HH4R H4R H4 receptor GPRv53 GPCR105 G-protein coupled receptor 105 AXOR35 [ Show all ]
Disease	Allergic rhinitis Asthma Inflammatory disease Rheumatoid arthritis
Length	390
Amino acid sequence	MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
UniProt	Q9H3N8
Protein Data Bank	N/A
GPCR-HGmod model	Q9H3N8
3D structure model	This predicted structure model is from GPCR-EXP Q9H3N8.
BioLiP	N/A
Therapeutic Target Database	T26500
ChEMBL	CHEMBL3759
IUPHAR	265
DrugBank	BE0000146

Ligand

Name	BRN 0805832
Molecular formula	C13H15ClN4O
IUPAC name	6-chloro-2-(4-methylpiperazin-1-yl)-3H-quinazolin-4-one
Molecular weight	278.74
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	1.1
Synonyms	AC1L1Z3J VUF-10331 4(3H)-Quinazolinone, 6-chloro-2-(4-methyl-1-piperazinyl)- 6-Chloro-2-(4-methyl-1-piperazinyl)-4(3H)-quinazolinone LS-140512 BDBM50397301 5-25-15-00060 (Beilstein Handbook Reference) CHEMBL471712 6-chloro-2-(4-methylpiperazin-1-yl)-1H-quinazolin-4-one SCHEMBL13545523 33017-92-4 DTXSID80186654 [ Show all ]
Inchi Key	BNASSGFQLMOZKG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H15ClN4O/c1-17-4-6-18(7-5-17)13-15-11-3-2-9(14)8-10(11)12(19)16-13/h2-3,8H,4-7H2,1H3,(H,15,16,19)
PubChem CID	135570464
ChEMBL	CHEMBL471712
IUPHAR	N/A
BindingDB	50397301
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	15135.6 nM	PMID19053770	BindingDB,ChEMBL

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