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GLASS

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GPCR

Name	Gastric inhibitory polypeptide receptor
Species	Homo sapiens (Human)
Gene	GIPR
Synonym	GIP-R GIP receptor Glucose-dependent insulinotropic polypeptide receptor Gippr
Disease	Type 2 diabetes
Length	466
Amino acid sequence	MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC
UniProt	P48546
Protein Data Bank	N/A
GPCR-HGmod model	P48546
3D structure model	This predicted structure model is from GPCR-EXP P48546.
BioLiP	N/A
Therapeutic Target Database	T41750
ChEMBL	CHEMBL4383
IUPHAR	248
DrugBank	N/A

Ligand

Name	CHEMBL452311
Molecular formula	C30H32BrN3O5
IUPAC name	(2R)-3-[[4-[[N-[(3-bromophenyl)carbamoyl]-4-cyclohexylanilino]methyl]benzoyl]amino]-2-hydroxypropanoic acid
Molecular weight	594.506
Hydrogen bond acceptor	5
Hydrogen bond donor	4
XlogP	5.6
Synonyms	(R)-3-{4-[3-(3-Bromophenyl)-1-(4-cyclohexylphenyl)ureidomethyl]benzovlamino}-2-hydroxypropionic Acid BDBM50244506 QJEGIIJPDLHOEZ-HHHXNRCGSA-N (R)-3-{4-[3-(3-Bromophenyl)-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino}-2-hydroxypropionic acid (R)-3-[4-[3-(3-Bromophenyl)-1-(4-cyclohexylphenyl)ureidomethy]benzoylamino]-2-hydroxypropionic Acid SCHEMBL2651415 [ Show all ]
Inchi Key	QJEGIIJPDLHOEZ-HHHXNRCGSA-N
Inchi ID	InChI=1S/C30H32BrN3O5/c31-24-7-4-8-25(17-24)33-30(39)34(26-15-13-22(14-16-26)21-5-2-1-3-6-21)19-20-9-11-23(12-10-20)28(36)32-18-27(35)29(37)38/h4,7-17,21,27,35H,1-3,5-6,18-19H2,(H,32,36)(H,33,39)(H,37,38)/t27-/m1/s1
PubChem CID	10282059
ChEMBL	CHEMBL452311
IUPHAR	N/A
BindingDB	50244506
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	216.0 nM	PMID18707090	BindingDB,ChEMBL

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