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GPCR

NameHistamine H2 receptor
SpeciesMus musculus (Mouse)
GeneHrh2
SynonymGastric receptor I
H2 receptor
H2R
HH2R
DiseaseN/A for non-human GPCRs
Length397
Amino acid sequenceMEPNGTVHSCCLDSIALKVTISVVLTTLIFITVAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVMPFSAIYQLSFKWSFGQVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGMVTFYLPLLIMCVTYYRIFKIAREQAKRINHISSWKAATIREHKATVTLAAVMGAFIVCWFPYFTAFVYRGLRGDDAVNEVVEGIVLWLGYANSALNPILYATLNRDFRMAYQQLFHCKLASHNSHKTSLRLNNSLLSRSQSREGRWQEEKPLKLQVWSGTELTHPQGSPVRTRLSHSSCLLSLSLLSFIWKLGTWIHHRRPFQPSLHISA
UniProtP97292
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2245
IUPHARN/A
DrugBankN/A

Ligand

NameHtmt-6
Molecular formulaC19H28N4O
IUPAC name6-[2-(1H-imidazol-5-yl)ethylamino]-N-(4-methylphenyl)heptanamide
Molecular weight328.46
Hydrogen bond acceptor3
Hydrogen bond donor3
XlogP2.6
Synonyms6-((2-(4-Imidazolyl)ethyl)amino)heptanoic acid 4-toluidide
6-[2-(1H-imidazol-5-yl)ethylamino]-N-(4-methylphenyl)heptanamide
CHEMBL291607
103827-15-2
AC1L3Z6Y
Inchi KeyQNIVPXHOVMGAFZ-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H28N4O/c1-15-7-9-17(10-8-15)23-19(24)6-4-3-5-16(2)21-12-11-18-13-20-14-22-18/h7-10,13-14,16,21H,3-6,11-12H2,1-2H3,(H,20,22)(H,23,24)
PubChem CID124845
ChEMBLCHEMBL291607
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Relative potency3.0 -PMID2959777ChEMBL

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