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GLASS

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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	CHEMBL209480
Molecular formula	C15H9F3N2O
IUPAC name	3-[3-(trifluoromethyl)phenyl]imino-1H-indol-2-one
Molecular weight	290.245
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	3.4
Synonyms	3-[3-(Trifluoromethyl)phenylimino]-1H-indole-2(3H)-one AKOS001585742 DTXSID10350548 STK795436 1351286-66-2 BNSKFCOAYKYHCS-UHFFFAOYSA-N MolPort-001-928-433 3-(3-Trifluoromethyl-phenylimino)-1,3-dihydro-indol-2-one AC1LE8UH SR-01000312373 3-{[3-(trifluoromethyl)phenyl]azamethylene}-1H-benzo[d]azolin-2-one BAS 00382582 HMS1545D13 TimTec1_003951 1H-Indol-2-one, 3-[[3-(trifluoromethyl)phenyl]imino]- 61294-07-3 CBDivE_011568 MolPort-002-134-948 3-[3-(trifluoromethyl)anilino]indol-2-one AKOS000520057 CTK2E3215 SR-01000312373-1 (3Z)-3-{[3-(trifluoromethyl)phenyl]imino}-1,3-dihydro-2H-indol-2-one 3-{[3-(trifluoromethyl)phenyl]azamethylene}benzo[d]azolidin-2-one BDBM50189595 MCULE-2258255673 ZINC12377202 2H-Indol-2-one, 1,3-dihydro-3-[[3-(trifluoromethyl)phenyl]imino]- A1264/0057815 SCHEMBL2217473 [ Show all ]
Inchi Key	BNSKFCOAYKYHCS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H9F3N2O/c16-15(17,18)9-4-3-5-10(8-9)19-13-11-6-1-2-7-12(11)20-14(13)21/h1-8H,(H,19,20,21)
PubChem CID	135411930
ChEMBL	CHEMBL209480
IUPHAR	N/A
BindingDB	50189595
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	596.0 nM	PMID16789730	BindingDB,ChEMBL

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