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Name | Thyrotropin-releasing hormone receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Trhr |
Synonym | Thyroliberin receptor TRH receptor TRH-R TRH-R1 TRH1 receptor |
Disease | N/A for non-human GPCRs |
Length | 412 |
Amino acid sequence | MENETVSELNQTELPPQVAVALEYQVVTILLVVVICGLGIVGNIMVVLVVMRTKHMRTATNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVMPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNKNMNLNTTNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKESDRFSTELDDITVTDTYVSTTKVSFDDTCLASEKNGPSSCTYGYSLTAKQEKI |
UniProt | Q01717 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4553 |
IUPHAR | 363 |
DrugBank | N/A |
Name | CHEMBL2371831 |
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Molecular formula | C20H27N6O5+ |
IUPAC name | 1-[(3S)-4-[(2S)-2-carbamoylpyrrolidin-1-yl]-4-oxo-3-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]butyl]pyridin-1-ium-3-carboxamide |
Molecular weight | 431.473 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 4 |
XlogP | -2.7 |
Synonyms | N/A |
Inchi Key | QUILMVVCZFJPCG-KKUMJFAQSA-O |
Inchi ID | InChI=1S/C20H26N6O5/c21-17(28)12-3-1-8-25(11-12)10-7-14(24-19(30)13-5-6-16(27)23-13)20(31)26-9-2-4-15(26)18(22)29/h1,3,8,11,13-15H,2,4-7,9-10H2,(H5-,21,22,23,24,27,28,29,30)/p+1/t13-,14-,15-/m0/s1 |
PubChem CID | 73345598 |
ChEMBL | CHEMBL2371831 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | <10000.0 nM | PMID15537357 | ChEMBL |
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