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GPCR

NameNociceptin receptor
SpeciesHomo sapiens (Human)
GeneOPRL1
SynonymOrphanin FQ receptor
OP4
NOPr
NOP-r
NOP receptor
[ Show all ]
DiseaseInflammatory disease
Major depressive disorder
Central nervous system disease
Heart failure
Anxiety disorder
[ Show all ]
Length370
Amino acid sequenceMEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
UniProtP41146
Protein Data Bank5dhh, 5dhg, 4ea3
GPCR-HGmod modelP41146
3D structure modelThis structure is from PDB ID 5dhh.
BioLiPBL0328039,BL0328040, BL0328041,BL0328042, BL0227293,BL0227294
Therapeutic Target DatabaseT52921
ChEMBLCHEMBL2014
IUPHAR320
DrugBankBE0002378

Ligand

NameCHEMBL378394
Molecular formulaC23H24ClN3O
IUPAC name2-[2-[5-[2-(4-chlorophenyl)ethyl]-1,3-oxazol-2-yl]-1H-indol-4-yl]-N,N-dimethylethanamine
Molecular weight393.915
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP5.3
SynonymsBDBM50185540
2-(2-(5-(4-chlorophenethyl)oxazol-2-yl)-1H-indol-4-yl)-N,N-dimethylethanamine
Inchi KeyBOOMWXGTPLEZGU-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H24ClN3O/c1-27(2)13-12-17-4-3-5-21-20(17)14-22(26-21)23-25-15-19(28-23)11-8-16-6-9-18(24)10-7-16/h3-7,9-10,14-15,26H,8,11-13H2,1-2H3
PubChem CID44413175
ChEMBLCHEMBL378394
IUPHARN/A
BindingDB50185540
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC50<1000.0 nMPMID16621546BindingDB,ChEMBL
Inhibition37.0 %PMID16621546ChEMBL

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