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GPCR

Name5-hydroxytryptamine receptor 1B
SpeciesRattus norvegicus (Rat)
GeneHtr1b
SynonymHTR1D2
5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
5-HT1Dbeta
5-HT1DB
5-HT1B serotonin receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length386
Amino acid sequenceMEEQGIQCAPPPPATSQTGVPLANLSHNCSADDYIYQDSIALPWKVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVDYSAKRTPKRAAIMIVLVWVFSISISLPPFFWRQAKAEEEVLDCFVNTDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRILKQTPNKTGKRLTRAQLITDSPGSTSSVTSINSRVPEVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHMAIFDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTG
UniProtP28564
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3459
IUPHAR2
DrugBankN/A

Ligand

Nameserotonin
Molecular formulaC10H12N2O
IUPAC name3-(2-aminoethyl)-1H-indol-5-ol
Molecular weight176.219
Hydrogen bond acceptor2
Hydrogen bond donor3
XlogP0.2
SynonymsL000078
6F7FD5B4-A558-45F0-A20A-2D068A3EFE6A
NCGC00015525-03
Antemovis
NCGC00142449-02
[ Show all ]
Inchi KeyQZAYGJVTTNCVMB-UHFFFAOYSA-N
Inchi IDInChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
PubChem CID5202
ChEMBLCHEMBL39
IUPHAR5
BindingDB10755
DrugBankDB08839

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5026.0 nMPMID2374139BindingDB,ChEMBL
IC504.6 nMPMID9357534BindingDB,ChEMBL
IC504.9 nMPMID26988801, PMID27876250BindingDB,ChEMBL
IC505.0 nMPMID2374139BindingDB,ChEMBL
Ki0.57 nMPMID7984267BindingDB
Ki1.1 nMPMID9513601, PMID10229626BindingDB,ChEMBL
Ki2.5 nMPMID7629808BindingDB,ChEMBL
Ki2.512 nMPMID10543880ChEMBL
Ki2.6 nMPMID8935801BindingDB
Ki3.0 nMPMID8584042BindingDB
Ki3.01 nMPMID7984267BindingDB
Ki3.467 nMPMID3385733ChEMBL
Ki5.0 nMPMID2299641BindingDB,ChEMBL
Ki5.24 nMPMID7984267BindingDB
Ki5.4 nMPMID2965244, PMID8071931BindingDB,ChEMBL
Ki14.0 nMPMID1738111BindingDB
Ki15.84 nMPMID7984267BindingDB
Ki25.0 nMPMID3543362BindingDB,ChEMBL

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