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GPCR

NameGalanin receptor type 3
SpeciesHomo sapiens (Human)
GeneGALR3
SynonymGAL3-R
Galnr3
GALR-3
GALR3
GAL3 receptor
DiseaseCognitive disorders
Length368
Amino acid sequenceMADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProtO60755
Protein Data BankN/A
GPCR-HGmod modelO60755
3D structure modelThis predicted structure model is from GPCR-EXP O60755.
BioLiPN/A
Therapeutic Target DatabaseT98494
ChEMBLCHEMBL2731
IUPHAR245
DrugBankN/A

Ligand

NameMLS000538535
Molecular formulaC15H15BrN2O2
IUPAC name2-(4-bromo-2,5-dimethylphenoxy)-N-pyridin-4-ylacetamide
Molecular weight335.201
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP3.1
Synonyms2-(4-bromo-2,5-dimethylphenoxy)-N-pyridin-4-ylacetamide
HMS2441A21
AKOS022155538
MolPort-002-293-338
2-(4-bromo-2,5-dimethyl-phenoxy)-N-(4-pyridyl)acetamide
[ Show all ]
Inchi KeyBOQVYTIYMDHSSL-UHFFFAOYSA-N
Inchi IDInChI=1S/C15H15BrN2O2/c1-10-8-14(11(2)7-13(10)16)20-9-15(19)18-12-3-5-17-6-4-12/h3-8H,9H2,1-2H3,(H,17,18,19)
PubChem CID1254286
ChEMBLCHEMBL1417355
IUPHARN/A
BindingDB97070
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC501401.0 nM, PubChem BioAssay data setBindingDB,ChEMBL

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