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GPCR

NameD(3) dopamine receptor
SpeciesRattus norvegicus (Rat)
GeneDrd3
SynonymD3 receptor
D3R
Dopamine D3 receptor
dopaminergic receptor D3
DiseaseN/A for non-human GPCRs
Length446
Amino acid sequenceMAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
UniProtP19020
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3138
IUPHAR216
DrugBankN/A

Ligand

NameCHEMBL52300
Molecular formulaC24H31BrN2O2
IUPAC name4-bromo-N-[[(2R)-1-cycloheptylpyrrolidin-2-yl]methyl]-1-methoxynaphthalene-2-carboxamide
Molecular weight459.428
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP6.1
SynonymsBDBM50099796
N-[[(2R)-1-Cycloheptyl-2-pyrrolidinyl]methyl]-1-methoxy-4-bromo-2-naphthalenecarboxamide
4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1-cycloheptyl-pyrrolidin-2-ylmethyl)-amide
Inchi KeyBOSOVNGIOQDIAC-GOSISDBHSA-N
Inchi IDInChI=1S/C24H31BrN2O2/c1-29-23-20-13-7-6-12-19(20)22(25)15-21(23)24(28)26-16-18-11-8-14-27(18)17-9-4-2-3-5-10-17/h6-7,12-13,15,17-18H,2-5,8-11,14,16H2,1H3,(H,26,28)/t18-/m1/s1
PubChem CID10766338
ChEMBLCHEMBL52300
IUPHARN/A
BindingDB50099796
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki2.4 nMPMID11356115BindingDB,ChEMBL

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