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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Orexin receptor type 2
Species	Rattus norvegicus (Rat)
Gene	Hcrtr2
Synonym	hypocretin receptor 2 Hypocretin receptor type 2 hypocretin (orexin) receptor 2 orexin receptor type 2 Ox-2-R OX2 receptor Ox2-R OX2R [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV
UniProt	P56719
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1275216
IUPHAR	322
DrugBank	N/A

Ligand

Name	SCHEMBL1716967
Molecular formula	C22H25N5O2
IUPAC name	[(2R,5R)-2-methyl-5-[(6-methylpyridin-2-yl)oxymethyl]piperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
Molecular weight	391.475
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	3.9
Synonyms	US8569311, C-4 CHEMBL3655665 BDBM104691
Inchi Key	RAGJBUUPALHONH-QZTJIDSGSA-N
Inchi ID	InChI=1S/C22H25N5O2/c1-16-6-5-9-21(25-16)29-15-18-11-10-17(2)26(14-18)22(28)19-7-3-4-8-20(19)27-23-12-13-24-27/h3-9,12-13,17-18H,10-11,14-15H2,1-2H3/t17-,18-/m1/s1
PubChem CID	25127820
ChEMBL	CHEMBL3655665
IUPHAR	N/A
BindingDB	104691
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	0.67 nM	, None	BindingDB,ChEMBL

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