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Name | Gonadotropin-releasing hormone receptor |
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Species | Homo sapiens (Human) |
Gene | GNRHR |
Synonym | LHRHR GnRH I receptor Type I GnRHR gnRH receptor GnRH-R [ Show all ] |
Disease | Uterine leiomyoma Hypothalamic hypogonadism Ovulation Prostate cancer Prostate disease [ Show all ] |
Length | 328 |
Amino acid sequence | MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL |
UniProt | P30968 |
Protein Data Bank | N/A |
GPCR-HGmod model | P30968 |
3D structure model | This predicted structure model is from GPCR-EXP P30968. |
BioLiP | N/A |
Therapeutic Target Database | T12475 |
ChEMBL | CHEMBL1855 |
IUPHAR | 256 |
DrugBank | BE0000203 |
Name | T 98475 |
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Molecular formula | C37H37F2N3O4S |
IUPAC name | propan-2-yl 3-[[benzyl(methyl)amino]methyl]-7-[(2,6-difluorophenyl)methyl]-2-[4-(2-methylpropanoylamino)phenyl]-4-oxothieno[2,3-b]pyridine-5-carboxylate |
Molecular weight | 657.777 |
Hydrogen bond acceptor | 9 |
Hydrogen bond donor | 1 |
XlogP | 7.5 |
Synonyms | 199119-18-1 CHEMBL544440 GTPL1184 Propan-2-yl 3-((benzyl(methyl)amino)methyl)-7-((2,6-difluorophenyl)methyl)-2-(4-(2-methylpropanoylamino)phenyl)-4-oxothieno(2,3-b)pyridine-5-carboxylate UNII-F1KLT23O3A [ Show all ] |
Inchi Key | RANJJVIMTOIWIN-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C37H37F2N3O4S/c1-22(2)35(44)40-26-16-14-25(15-17-26)34-28(19-41(5)18-24-10-7-6-8-11-24)32-33(43)29(37(45)46-23(3)4)21-42(36(32)47-34)20-27-30(38)12-9-13-31(27)39/h6-17,21-23H,18-20H2,1-5H3,(H,40,44) |
PubChem CID | 9874838 |
ChEMBL | CHEMBL71917 |
IUPHAR | 1184 |
BindingDB | 50067485 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 0.199526 nM | PMID9784092 | IUPHAR |
IC50 | 0.2 nM | PMID11814806, PMID12127532 | BindingDB |
IC50 | 0.2 nM | PMID11814806, PMID18419112, PMID12502365, PMID16789738, PMID12127532 | BindingDB,ChEMBL |
IC50 | 0.2 nM | PMID9784092 | BindingDB |
IC50 | 0.6 nM | PMID12502365, PMID16789738 | BindingDB,ChEMBL |
IC50 | 2.0 nM | PMID12502365, PMID16789738 | BindingDB,ChEMBL |
IC50 | 4.0 nM | PMID16789738 | BindingDB,ChEMBL |
IC50 | 60.0 nM | PMID15715483 | BindingDB,ChEMBL |
Ki | 0.2 nM | PMID14505682 | BindingDB |
Ki | 0.2 nM | PMID14505682 | ChEMBL |
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