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GPCR

Name5-hydroxytryptamine receptor 6
SpeciesRattus norvegicus (Rat)
GeneHtr6
Synonym5-HT-6
5-HT6
5-HT6 receptor
5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
Serotonin receptor 6
[ Show all ]
DiseaseN/A for non-human GPCRs
Length436
Amino acid sequenceMVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPGQCRLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTAGQALETLQVPRTPRPGMESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPPPCGPLTAVPDQASACSRCCLCLCRQTQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWSTSLSQTLWSLRYGRIHSVPP
UniProtP31388
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3372
IUPHAR11
DrugBankN/A

Ligand

Namerisperidone
Molecular formulaC23H27FN4O2
IUPAC name3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
Molecular weight410.493
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP2.7
SynonymsRisperidone, Pharmaceutical Secondary Standard; Certified Reference Material
Rispolin
SPBio_003078
Tox21_110253
NSC-759895
[ Show all ]
Inchi KeyRAPZEAPATHNIPO-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3
PubChem CID5073
ChEMBLCHEMBL85
IUPHAR96
BindingDB50001885
DrugBankDB00734

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki398.107 - 1000.0 nMPMID8997630, PMID7908055IUPHAR
Ki420.0 nMPMID8935801, PMID9430133BindingDB
Ki425.0 nMPMID7908055BindingDB
Ki430.0 nMPMID9430133BindingDB
Ki1122.0 nMPMID8997630BindingDB

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