Zhang Lab

University of Michigan

Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only

Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●DMFold ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
Go back to previous page.

GPCR

Name	Thyrotropin receptor
Species	Homo sapiens (Human)
Gene	TSHR
Synonym	LGR3 Thyroid-stimulating hormone receptor Thyrotropin Receptor TSH receptor TSH-R
Disease	Thyroid cancer diagnosis Diagnostic test to differentiate primary and secondary hypothyroidism Thyroid cancer
Length	764
Amino acid sequence	MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQVQKVTHDMRQGLHNMEDVYELIENSHLTPKKQGQISEEYMQTVL
UniProt	P16473
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T60606
ChEMBL	CHEMBL1963
IUPHAR	255
DrugBank	N/A

Ligand

Name	n-oleoylethanolamine
Molecular formula	C20H39NO2
IUPAC name	(Z)-N-(2-hydroxyethyl)octadec-9-enamide
Molecular weight	325.537
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	6.3
Synonyms	Oleic acid monoethanolamide AK116336 SMR001230650 C20792 Tox21_500942 EINECS 203-884-8 KB-258121 MolPort-003-959-060 N-(cis-9-octadecenoyl) ethanolamine N-oleoyl ethanolamine NCGC00015761-03 (9Z)-N-(2-Hydroxyethyl)-9-octadecenamide NCGC00025182-05 Oleoyl monoethanolamide AX8017536 SR-01000076041-1 UNII-C80684146D component BOWVQLFMWHZBEF-KTKRTIGZSA-N HMS2233E21 Lopac0_000942 N-(2-Hydroxyethyl)-9Z-octadecenamide N-(Hydroxyethyl)oleamide N-oleoylethanolamide NCGC00015761-06 (Z)-N-(2-hydroxyethyl)octadec-9-enamide O 0383 9-Octadecenamide, N-(2-hydroxyethyl)-, (Z)- AB1005568 Oleylethanolamide BS0139 ST24048305 D07MBC HY-107542 MFCD00045972 N-(9Z-octadecenoyl) ethanolamine N-OEA NCGC00015761-01 NCGC00025182-02 1HI5J9N8E6 Oleamide MEA oleoyl 1-ethanolamide AKOS015839895 Spectrum5_002037 CCG-205023 UNII-1HI5J9N8E6 EU-0100942 LMFA08040015 Monoethanolamine oleic acid amide N-(cis-9-Octadecenoyl)ethanolamine N-oleoyl ethanolamine, Oleoyl monoethanolamide, Oleoylethanolamide NCGC00015761-04 (9Z)-N-(2-hydroxyethyl)octadec-9-enamide NCGC00025182-06 9-Octadecenamide, N-(2-hydroxyethyl)- 9Z-octadecenoylethanolamide oleoylethanolamide BDBM29080 SR-01000076041-3 CHEMBL280065 W-109412 HMS3262N06 LP00942 N-(2-hydroxyethyl)octadec-9-enamide N-(Hydroxyethyl)oleamide; N-(cis-9-Octadecenoyl)ethanolamine; OEA, oleoylethanolamide NCGC00015761-07 111-58-0 O253 AC1NR2BS SCHEMBL177713 C18:1 anandamide, 9Z-octadecenoylethanolamide, powder Tocris-1484 DTXSID1044516 J10351 MLS002153155 N-(9Z-octadecenoyl)-ethanolamine N-oleoyl ethanolamide NCGC00015761-02 NCGC00025182-04 Oleic acid ethanolamide Oleoyl Ethanolamide AS-15152 SR-01000076041 CHEBI:71466 UNII-3VVG2UI23S component BOWVQLFMWHZBEF-KTKRTIGZSA-N GTPL2661 Lopac-O-0383 N-(2-Hydroxyethyl)-9-octadecenamide N-(hydroxyethyl) oleamide N-Oleoyl-2-aminoethanol NCGC00015761-05 (Z)-N-(2-hydroxyethyl)-9-octadecenamide NCGC00261627-01 9-Octadecenamide, N-(2-hydroxyethyl)-, (9Z)- A802386 Oleoylethanolamide (OEA) BOWVQLFMWHZBEF-KTKRTIGZSA-N SR-01000076041-8 CS-0028847 ZINC8034993 HMS3649J05 LS-97729 N-(2-Hydroxyethyl)oleamide N-2-Hydroxyethyl-9(Z)-octadecenamide N-Oleoylethanolamine, ~98% (TLC) NCGC00025182-01 111O580 OEA [ Show all ]
Inchi Key	BOWVQLFMWHZBEF-KTKRTIGZSA-N
Inchi ID	InChI=1S/C20H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)21-18-19-22/h9-10,22H,2-8,11-19H2,1H3,(H,21,23)/b10-9-
PubChem CID	5283454
ChEMBL	CHEMBL280065
IUPHAR	2661
BindingDB	29080
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Potency	5011.9 nM	PubChem BioAssay data set	ChEMBL
Potency	39810.7 nM	PubChem BioAssay data set	ChEMBL

zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218