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GLASS

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GPCR

Name	Cannabinoid receptor 2
Species	Homo sapiens (Human)
Gene	CNR2
Synonym	Peripheral cannabinoid receptor rCB2 hCB2 cannabinoid receptor 2 (macrophage) cannabinoid receptor 2 (spleen) CB-2 CB2 CB2 receptor CB2-R CX5 [ Show all ]
Disease	Immune disorder Inflammatory bowel disease Inflammatory disease Neuropathic pain Osteoporosis Pain Atopic dermatitis Rheumatoid arthritis [ Show all ]
Length	360
Amino acid sequence	MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
UniProt	P34972
Protein Data Bank	5zty
GPCR-HGmod model	P34972
3D structure model	This structure is from PDB ID 5zty.
BioLiP	BL0438927
Therapeutic Target Database	T37693
ChEMBL	CHEMBL253
IUPHAR	57
DrugBank	BE0000095

Ligand

Name	n-oleoylethanolamine
Molecular formula	C20H39NO2
IUPAC name	(Z)-N-(2-hydroxyethyl)octadec-9-enamide
Molecular weight	325.537
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	6.3
Synonyms	UNII-1HI5J9N8E6 EU-0100942 LMFA08040015 Monoethanolamine oleic acid amide N-(cis-9-Octadecenoyl)ethanolamine N-oleoyl ethanolamine, Oleoyl monoethanolamide, Oleoylethanolamide NCGC00015761-04 (9Z)-N-(2-hydroxyethyl)octadec-9-enamide NCGC00025182-06 9-Octadecenamide, N-(2-hydroxyethyl)- oleoyl 1-ethanolamide AKOS015839895 Spectrum5_002037 CCG-205023 CHEMBL280065 W-109412 HMS3262N06 LP00942 N-(2-hydroxyethyl)octadec-9-enamide N-(Hydroxyethyl)oleamide; N-(cis-9-Octadecenoyl)ethanolamine; OEA, oleoylethanolamide NCGC00015761-07 111-58-0 O253 9Z-octadecenoylethanolamide oleoylethanolamide BDBM29080 SR-01000076041-3 DTXSID1044516 J10351 MLS002153155 N-(9Z-octadecenoyl)-ethanolamine N-oleoyl ethanolamide NCGC00015761-02 NCGC00025182-04 Oleic acid ethanolamide AC1NR2BS SCHEMBL177713 C18:1 anandamide, 9Z-octadecenoylethanolamide, powder Tocris-1484 UNII-3VVG2UI23S component BOWVQLFMWHZBEF-KTKRTIGZSA-N GTPL2661 Lopac-O-0383 N-(2-Hydroxyethyl)-9-octadecenamide N-(hydroxyethyl) oleamide N-Oleoyl-2-aminoethanol NCGC00015761-05 (Z)-N-(2-hydroxyethyl)-9-octadecenamide NCGC00261627-01 9-Octadecenamide, N-(2-hydroxyethyl)-, (9Z)- Oleoyl Ethanolamide AS-15152 SR-01000076041 CHEBI:71466 CS-0028847 ZINC8034993 HMS3649J05 LS-97729 N-(2-Hydroxyethyl)oleamide N-2-Hydroxyethyl-9(Z)-octadecenamide N-Oleoylethanolamine, ~98% (TLC) NCGC00025182-01 111O580 OEA A802386 Oleoylethanolamide (OEA) BOWVQLFMWHZBEF-KTKRTIGZSA-N SR-01000076041-8 Tox21_500942 EINECS 203-884-8 KB-258121 MolPort-003-959-060 N-(cis-9-octadecenoyl) ethanolamine N-oleoyl ethanolamine NCGC00015761-03 (9Z)-N-(2-Hydroxyethyl)-9-octadecenamide NCGC00025182-05 Oleic acid monoethanolamide AK116336 SMR001230650 C20792 UNII-C80684146D component BOWVQLFMWHZBEF-KTKRTIGZSA-N HMS2233E21 Lopac0_000942 N-(2-Hydroxyethyl)-9Z-octadecenamide N-(Hydroxyethyl)oleamide N-oleoylethanolamide NCGC00015761-06 (Z)-N-(2-hydroxyethyl)octadec-9-enamide O 0383 9-Octadecenamide, N-(2-hydroxyethyl)-, (Z)- Oleoyl monoethanolamide AX8017536 SR-01000076041-1 D07MBC HY-107542 MFCD00045972 N-(9Z-octadecenoyl) ethanolamine N-OEA NCGC00015761-01 NCGC00025182-02 1HI5J9N8E6 Oleamide MEA AB1005568 Oleylethanolamide BS0139 ST24048305 [ Show all ]
Inchi Key	BOWVQLFMWHZBEF-KTKRTIGZSA-N
Inchi ID	InChI=1S/C20H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)21-18-19-22/h9-10,22H,2-8,11-19H2,1H3,(H,21,23)/b10-9-
PubChem CID	5283454
ChEMBL	CHEMBL280065
IUPHAR	2661
BindingDB	29080
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID19361197, PMID16570929	BindingDB,ChEMBL

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