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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Rattus norvegicus (Rat)
Gene	Htr4
Synonym	5-HT-4 5-HT4 5-HT4 receptor 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled serotonin receptor 4
Disease	N/A for non-human GPCRs
Length	406
Amino acid sequence	MDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
UniProt	Q62758
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4317
IUPHAR	9
DrugBank	N/A

Ligand

Name	CHEMBL303877
Molecular formula	C18H22ClN3O3
IUPAC name	4-acetamido-N-(3-azatricyclo[3.3.1.03,7]nonan-9-yl)-5-chloro-2-methoxybenzamide
Molecular weight	363.842
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	1.7
Synonyms	SCHEMBL7356235 BDBM50289988 L013522 4-Acetylamino-N-(3-aza-tricyclo[3.3.1.03,7]non-9-yl)-5-chloro-2-methoxy-benzamide
Inchi Key	BOZRGVLESXHQJV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H22ClN3O3/c1-9(23)20-15-6-16(25-2)13(5-14(15)19)18(24)21-17-10-3-12-4-11(17)8-22(12)7-10/h5-6,10-12,17H,3-4,7-8H2,1-2H3,(H,20,23)(H,21,24)
PubChem CID	22400452
ChEMBL	CHEMBL303877
IUPHAR	N/A
BindingDB	50289988
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<10000.0 nM	, Bioorg. Med. Chem. Lett., (1997) 7:17:2149	BindingDB,ChEMBL
EC50	3335.0 nM	, Bioorg. Med. Chem. Lett., (1997) 7:17:2149	BindingDB,ChEMBL

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