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Name | Melanin-concentrating hormone receptor 1 |
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Species | Homo sapiens (Human) |
Gene | MCHR1 |
Synonym | SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R [ Show all ] |
Disease | Obesity Obesity; Anxiety; Depression |
Length | 422 |
Amino acid sequence | MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT |
UniProt | Q99705 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q99705 |
3D structure model | This predicted structure model is from GPCR-EXP Q99705. |
BioLiP | N/A |
Therapeutic Target Database | T09572 |
ChEMBL | CHEMBL344 |
IUPHAR | 280 |
DrugBank | BE0003478 |
Name | CHEMBL197429 |
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Molecular formula | C28H28ClFN4O |
IUPAC name | 3-(3-chloro-4-fluorophenyl)-1-[[4-(3-cyanophenyl)phenyl]methyl]-1-(3-pyrrolidin-1-ylpropyl)urea |
Molecular weight | 491.007 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 5.6 |
Synonyms | BDBM50174828 3-(3-chloro-4-fluoro-phenyl)-1-(3''-cyano-biphenyl-4-ylmethyl)-1-(3-pyrrolidin-1-yl-propyl)-urea |
Inchi Key | BPFHLARZSZGTAE-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C28H28ClFN4O/c29-26-18-25(11-12-27(26)30)32-28(35)34(16-4-15-33-13-1-2-14-33)20-21-7-9-23(10-8-21)24-6-3-5-22(17-24)19-31/h3,5-12,17-18H,1-2,4,13-16,20H2,(H,32,35) |
PubChem CID | 44405421 |
ChEMBL | CHEMBL197429 |
IUPHAR | N/A |
BindingDB | 50174828 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 48.0 nM | PMID16202583 | BindingDB,ChEMBL |
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