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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Vasopressin V2 receptor
Species	Sus scrofa (Pig)
Gene	AVPR2
Synonym	Antidiuretic hormone receptor AVPR V2 Renal-type arginine vasopressin receptor V2R
Disease	N/A for non-human GPCRs
Length	370
Amino acid sequence	MLRATTSAVPRALSWPAAPGNGSEREPLDDRDPLLARVELALLSTVFVAVALSNGLVLGALVRRGRRGRWAPMHVFIGHLCLADLAVALFQVLPQLAWDATYRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGDGSGVLDCWASFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHTSLVPGPAERAGGHRGGRRAGSPREGARVSAAMAKTARMTLVIVAVYVLCWAPFFLVQLWSVWDPKAPREGPPFVLLMLLASLNSCTNPWIYASFSSSISSELRSLLCCPRRRTPPSLRPQEESCATASSFSARDTSS
UniProt	P32307
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3944
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL411587
Molecular formula	C50H73N13O11S2
IUPAC name	(2S)-N-[(2R)-1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(4S,7R,10S,13R,16R)-7-(2-amino-2-oxoethyl)-13-benzyl-16-[(4-ethoxyphenyl)methyl]-20,20-dimethyl-6,9,12,15,18-pentaoxo-10-propan-2-yl-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
Molecular weight	1096.33
Hydrogen bond acceptor	14
Hydrogen bond donor	11
XlogP	-0.6
Synonyms	N/A
Inchi Key	RHLYUMPLHSJBPY-TUHVAHTNSA-N
Inchi ID	InChI=1S/C50H73N13O11S2/c1-6-74-31-18-16-30(17-19-31)23-33-43(68)59-34(22-29-12-8-7-9-13-29)45(70)62-41(28(2)3)47(72)60-35(24-38(51)64)44(69)61-36(27-75-76-50(4,5)25-40(66)57-33)48(73)63-21-11-15-37(63)46(71)58-32(14-10-20-55-49(53)54)42(67)56-26-39(52)65/h7-9,12-13,16-19,28,32-37,41H,6,10-11,14-15,20-27H2,1-5H3,(H2,51,64)(H2,52,65)(H,56,67)(H,57,66)(H,58,71)(H,59,68)(H,60,72)(H,61,69)(H,62,70)(H4,53,54,55)/t32-,33-,34-,35-,36-,37+,41+/m1/s1
PubChem CID	44318009
ChEMBL	CHEMBL411587
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
K bind	39.0 nM	PMID2946863	ChEMBL

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