You can:
Name | Histamine H3 receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | HRH3 |
Synonym | HH3R H3R H3 receptor GPCR97 G-protein coupled receptor 97 |
Disease | Obese insulin-resistant disorders Excessive daytime sleepiness Sleep disorders Schizophrenia Pain [ Show all ] |
Length | 445 |
Amino acid sequence | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK |
UniProt | Q9Y5N1 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q9Y5N1 |
3D structure model | This predicted structure model is from GPCR-EXP Q9Y5N1. |
BioLiP | N/A |
Therapeutic Target Database | T64765 |
ChEMBL | CHEMBL264 |
IUPHAR | 264 |
DrugBank | BE0000968 |
Name | CHEMBL2048586 |
---|---|
Molecular formula | C18H31N5OS |
IUPAC name | 2,6-dimethyl-4-[5-(4-piperidin-1-ylpiperidin-1-yl)-1,3,4-thiadiazol-2-yl]morpholine |
Molecular weight | 365.54 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 0 |
XlogP | 3.2 |
Synonyms | BDBM50386354 SCHEMBL12244670 |
Inchi Key | BPOGPSWQWXFRCB-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C18H31N5OS/c1-14-12-23(13-15(2)24-14)18-20-19-17(25-18)22-10-6-16(7-11-22)21-8-4-3-5-9-21/h14-16H,3-13H2,1-2H3 |
PubChem CID | 58430454 |
ChEMBL | CHEMBL2048586 |
IUPHAR | N/A |
BindingDB | 50386354 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 53.0 nM | PMID24900450 | BindingDB,ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218