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Name | C-C chemokine receptor type 2 |
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Species | Homo sapiens (Human) |
Gene | CCR2 |
Synonym | MCP-1-R Monocyte chemoattractant protein 1 receptor CKR2 MCP-1 receptor chemokine receptor CCR2 [ Show all ] |
Disease | Chronic obstructive pulmonary disease Neuropathic pain Multiple scierosis Metastatic cancer; Multiple scierosis Inflammatory disease [ Show all ] |
Length | 374 |
Amino acid sequence | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA |
UniProt | P41597 |
Protein Data Bank | 6gpx, 6gps |
GPCR-HGmod model | P41597 |
3D structure model | This structure is from PDB ID 6gpx. |
BioLiP | BL0437328,BL0437329, BL0437327, BL0437326, BL0437325 |
Therapeutic Target Database | T89988 |
ChEMBL | CHEMBL4015 |
IUPHAR | 59 |
DrugBank | N/A |
Name | CHEMBL362536 |
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Molecular formula | C19H23ClN4O2S |
IUPAC name | N'-[2-[3-[(4-chlorophenyl)methylamino]pyrrolidin-1-yl]acetyl]-4-methylthiophene-2-carbohydrazide |
Molecular weight | 406.929 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 3 |
XlogP | 3.0 |
Synonyms | BDBM50153954 4-Methyl-thiophene-2-carboxylic acid N''''-{2-[3-(4-chloro-benzylamino)-pyrrolidin-1-yl]-acetyl}-hydrazide |
Inchi Key | ADQWNJNQMVFWIM-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C19H23ClN4O2S/c1-13-8-17(27-12-13)19(26)23-22-18(25)11-24-7-6-16(10-24)21-9-14-2-4-15(20)5-3-14/h2-5,8,12,16,21H,6-7,9-11H2,1H3,(H,22,25)(H,23,26) |
PubChem CID | 44395238 |
ChEMBL | CHEMBL362536 |
IUPHAR | N/A |
BindingDB | 50153954 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 7800.0 nM | PMID15454236 | BindingDB,ChEMBL |
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