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Name | Histamine H1 receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | HRH1 |
Synonym | HH1R H1R Hisr H1 receptor |
Disease | Vertigo's disease; Meniere's disease Ocular allergy Obesity Nausea; Vomiting Insomnia; Anxiety disorder [ Show all ] |
Length | 487 |
Amino acid sequence | MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS |
UniProt | P35367 |
Protein Data Bank | 3rze |
GPCR-HGmod model | P35367 |
3D structure model | This structure is from PDB ID 3rze. |
BioLiP | BL0202178, BL0202179, BL0202180 |
Therapeutic Target Database | T77913 |
ChEMBL | CHEMBL231 |
IUPHAR | 262 |
DrugBank | BE0000442 |
Name | Histaprodifen |
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Molecular formula | C20H23N3 |
IUPAC name | 2-[2-(3,3-diphenylpropyl)-1H-imidazol-5-yl]ethanamine |
Molecular weight | 305.425 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 2 |
XlogP | 3.5 |
Synonyms | ZINC38881558 CHEMBL275507 2-[2-[3,3-di(phenyl)propyl]-3H-imidazol-4-yl]ethanamine BDBM22864 2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]ethan-1-amine [ Show all ] |
Inchi Key | BPZGZNLONLANFE-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C20H23N3/c21-14-13-18-15-22-20(23-18)12-11-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-10,15,19H,11-14,21H2,(H,22,23) |
PubChem CID | 10447834 |
ChEMBL | CHEMBL275507 |
IUPHAR | 4026 |
BindingDB | 22864 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Alpha | 0.69 - | PMID14667234 | ChEMBL |
IC50 | 794.0 nM | PMID14667234 | BindingDB |
IC50 | 794.33 nM | PMID14667234 | ChEMBL |
Ki | 1995.26 nM | PMID15947036 | IUPHAR |
Ki | 5.01187e+14 nM | PMID14667234 | ChEMBL |
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