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GPCR

Name	Beta-2 adrenergic receptor
Species	Cavia porcellus (Guinea pig)
Gene	Adrb2
Synonym	Beta-2 adrenoceptor Beta-2 adrenoreceptor
Disease	N/A for non-human GPCRs
Length	418
Amino acid sequence	MGHLGNGSDFLLAPNASHAPDHNVTRERDEAWVVGMAIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMNMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVVILMVWVVSGLTSFLPIQMHWYRATHKDAINCYAEETCCDFFTNQAYAIASSIVSFYLPLVVMVFVYSRVFQVAKKQLQKIDRSEGRFHTQNLSQVEQDGRSGHGLRRSSKFYLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIPKEVYILLNWVGYVNSAFNPLIYCRSPDFRIAFQELLCLRRSALKAYGNDCSSNSNGKTDYTGEPNVCHQGQEKERELLCEDPPGTEDLVSCPGTVPSDSIDSQGRNYSTNDSLL
UniProt	Q8K4Z4
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5414
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Arformoterol
Molecular formula	C19H24N2O4
IUPAC name	N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]phenyl]formamide
Molecular weight	344.411
Hydrogen bond acceptor	5
Hydrogen bond donor	4
XlogP	1.8
Synonyms	FORMOTEROL FUMARATE Innovair N-{2-hydroxy-5-[(1R)-1-hydroxy-2-{[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino}ethyl]phenyl}formamide UNII-F91H02EBWT (-)-Formoterol 49861-99-6 AKOS015969668 BDBM50151720 CS-1413 F91H02EBWT Foradil Formoterol/fluticasone propionate N-(2-hydroxy-5-((R)-1-hydroxy-2-((R)-1-(4-methoxyphenyl)propan-2-ylamino)ethyl)phenyl)formamide SB17482 YM-08316 126587-85-7 73573-87-2 Brovana (TN) D0E5FY Formamide, N-(2-hydroxy-5-(1-hydroxy-2-((2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)phenyl)-, (R-(R,R))- HSDB 7287 N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]phenyl]formamide Symbicort (TN) (+-)-2'-Hydroxy-5'-((RS)-1-hydroxy-2-(((RS)-p-methoxy-alpha-methylphenethyl)amino)ethyl)formanilide 289657-27-8 AC1MJ0T4 Arformoterol [INN] CHEMBL1363 DB01274 Formoterol [USAN:INN:BAN] MolPort-003-847-486 Racemic formoterol W-5127 (-)-Formoterol;Arformoterol;(R,R)-Formoterol AN-38345 BPZSYCZIITTYBL-YJYMSZOUSA-N D07463 Fluir Foradil/Foradile (Schering-Plough in the U.S., Novartis rest of world), Oxeze/Oxis (AstraZeneca), Atock (Astellas), Atimos/Atimos Modulite (Chiesi), and Perforomist (Dey) GTPL7479 N-(2-Hydroxy-5-{1-hydroxy-2-[2-(4-methoxy-phenyl)-1-methyl-ethylamino]-ethyl}-phenyl)-formamide SC-94426 ZINC2599970 183814-29-1 73F872 Arformoterol (INN) CHEBI:408174 D0P2AG formoterol HY-B0010A N-{2-hydroxy-5-[(1R)-1-hydroxy-2-({(1R)-1-methyl-2-[4-(methyloxy)phenyl]ethyl}amino)ethyl]phenyl}formamide UNII-5ZZ84GCW8B component BPZSYCZIITTYBL-YJYMSZOUSA-N (+-)-Formoterol 299964-45-7 AJ-44036 Atimos cid_9912089 eformoterol Formoterol/budesonide N-(2-Hydroxy-5-((R)-1-hydroxy-2-(((R)-1-(4-methoxyphenyl)propan-2-yl)amino)ethyl)phenyl)formamide rel-N-(2-Hydroxy-5-((R)-1-hydroxy-2-(((R)-1-(4-methoxyphenyl)propan-2-yl)amino)ethyl)phenyl)formamide X5000 (R,R)-Formoterol 67346-49-0 API0009091 Brovana D0D1DI Flutiform (TN) Formamide, N-(2-hydroxy-5-((1R)-1-hydroxy-2-(((1R)-2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)phenyl)- H98 N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methyl-ethyl]amino]ethyl]phenyl]formamide SCHEMBL4247 208102-40-3 Arformoterol tartrate [ Show all ]
Inchi Key	BPZSYCZIITTYBL-YJYMSZOUSA-N
Inchi ID	InChI=1S/C19H24N2O4/c1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22/h3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22)/t13-,19+/m1/s1
PubChem CID	3083544
ChEMBL	CHEMBL1363
IUPHAR	7479
BindingDB	50151720
DrugBank	DB01274
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	0.1259 nM	PMID24300734	ChEMBL
EC50	0.126 nM	PMID24300734	BindingDB
EC50	0.126 nM	PMID22297114	BindingDB
EC50	0.13 nM	PMID24300734	BindingDB
EC50	0.13 nM	PMID24300734	ChEMBL
EC50	0.3162 nM	PMID21696967	ChEMBL
EC50	0.316228 nM	PMID21696967, PMID21925889	BindingDB
FC	<1940.0 -	PMID21696967	ChEMBL
FC	20.0 -	PMID21696967	ChEMBL
IC50	0.4 nM	PMID20402514	BindingDB
IC50	0.4 nM	PMID20402514	ChEMBL
TIME	0.1667 hr	PMID21696967	ChEMBL
TIME	0.4667 hr	PMID20402514	ChEMBL
TIME	1.2 hr	PMID20402514	ChEMBL

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