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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Proteinase-activated receptor 1
Species	Homo sapiens (Human)
Gene	F2R
Synonym	Coagulation factor II receptor PAR-1 coagulation factor II (thrombin) receptor protease-activated receptor 1 Thrombin receptor PAR1 [ Show all ]
Disease	Thrombosis Restenosis Myocardial infarction Cancer Atherosclerosis Acute coronary syndrome [ Show all ]
Length	425
Amino acid sequence	MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
UniProt	P25116
Protein Data Bank	3vw7
GPCR-HGmod model	P25116
3D structure model	This structure is from PDB ID 3vw7.
BioLiP	BL0217099
Therapeutic Target Database	T36483
ChEMBL	CHEMBL3974
IUPHAR	347
DrugBank	BE0000928

Ligand

Name	2-methyl-N-[2-methyl-3-(propionylamino)phenyl]benzamide
Molecular formula	C18H20N2O2
IUPAC name	2-methyl-N-[2-methyl-3-(propanoylamino)phenyl]benzamide
Molecular weight	296.37
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	2.9
Synonyms	BRD-K66789582-001-01-8 ZINC12977847 2-methyl-N-[2-methyl-3-(propanoylamino)phenyl]benzamide KS-000046NR AN-329/43465271 STL089553 1090450-34-2 MCULE-4302182553 ARONIS24706 Z306561568 2-methyl-N-(2-methyl-3-propanamidophenyl)benzamide CHEMBL2047283 AKOS003571530 MolPort-006-360-487 [ Show all ]
Inchi Key	BQDYOVGQSJWZQQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H20N2O2/c1-4-17(21)19-15-10-7-11-16(13(15)3)20-18(22)14-9-6-5-8-12(14)2/h5-11H,4H2,1-3H3,(H,19,21)(H,20,22)
PubChem CID	25642843
ChEMBL	CHEMBL2047283
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	5.0 %	PMID22408714	ChEMBL

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