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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Type-2 angiotensin II receptor
Species	Rattus norvegicus (Rat)
Gene	Agtr2
Synonym	angiotensin II receptor, type 2 MRX88 Agtr2 AT2R AT2-R AT2 receptor angiotensin II receptor angiotensin receptor 2 Angiotensin II type-2 receptor angiotensin II type 2 receptor AT2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	363
Amino acid sequence	MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
UniProt	P35351
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL257
IUPHAR	35
DrugBank	N/A

Ligand

Name	CHEMBL61754
Molecular formula	C23H23ClN6O
IUPAC name	3-[[2-chloro-4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-5-ethyl-2-propylimidazole-4-carbaldehyde
Molecular weight	434.928
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	4.9
Synonyms	BDBM50283013 3-[3-Chloro-2''-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-5-ethyl-2-propyl-3H-imidazole-4-carbaldehyde
Inchi Key	BQGQWMOCPPBKOK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H23ClN6O/c1-3-7-22-25-20(4-2)21(14-31)30(22)13-16-11-10-15(12-19(16)24)17-8-5-6-9-18(17)23-26-28-29-27-23/h5-6,8-12,14H,3-4,7,13H2,1-2H3,(H,26,27,28,29)
PubChem CID	44303232
ChEMBL	CHEMBL61754
IUPHAR	N/A
BindingDB	50283013
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	500.0 nM	, Bioorg. Med. Chem. Lett., (1994) 4:16:2011	BindingDB,ChEMBL

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