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GPCR

Name	Mu-type opioid receptor
Species	Cavia porcellus (Guinea pig)
Gene	OPRM1
Synonym	M-OR-1 MOR-1
Disease	N/A for non-human GPCRs
Length	98
Amino acid sequence	YTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKTVNVCNWI
UniProt	P97266
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4354
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	morphine
Molecular formula	C17H19NO3
IUPAC name	(4R,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol
Molecular weight	285.343
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	0.8
Synonyms	Sevredol Infumorph MOI 4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol((Morphine)) Morphina [Italian] 4-methyl-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol(Morphine) Morphine 1.0 mg/ml in Methanol 7,8-Didehydro-4,5-epoxy-17-methyl-morphinan-3,6-diol MORPHINE, (5A,6A)-7,8-DIDEHYDRO-4,5-EPOXY-17-METHYLMORPHINIAN-3,6-DIOL, MORPHIUM, MORPHIA, DOLCONTIN, DUROMORPH, MORPHINA, NEPENTHE 9H-9,9c-Iminoethanophenanthro(4,5-bcd)furan-3,5-diol, 4alpha,5,7alpha,8-tetrahydro-12-methyl- MS Contin BIDD:GT0147 OMS Concentrate Cube juice Roxanol 100 Dimorf (-)(5.alpha.,6.alpha.)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol Duromorph (5alpha,6alpha)-17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol Substitol (TN) LS-91748 3-(4-Hydroxy-phenyl)-1-propyl-piperidine-3-carboxylic acid ethyl ester Morfina [Italian] 4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol(Morphine)(HCl) Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)- 57-27-2 Morphine Forte 76I7G6D29C Morphinum AN-23579 MS/S CCRIS 5762 Ospalivina D0WE3O Dreamer (-)Morphine sulfate Epitope ID:116646 (5R,6S,9R,13S,14R)-4,5-Epoxy-N-methyl-7-morphinen-3,6-diol SDZ 202-250 Unkie (morphine) 4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol Meconium 4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol ; HydroChloride Morphin [German] 4-methyl-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol Morphine (BAN) 6211-15-0 (sulfate (2:1) (salt) pentahydrate) MORPHINE SULFATE 863713-90-0 Morpho Avinza Nepenthe RMS Uniserts DEA No. 9300 Duramorph (1S,5R,13R,14S,17R)-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7,9,11(18),15-tetraene-10,14-diol Hocus Statex Drops Kadian 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol Morfina 4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol(morphine sulfate) Morphinan-3,6-alpha-diol, 7,8-didehydro-4,5-alpha-epoxy-17-methyl- 47106-99-0 Morphine Anhydrate 7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol Morphine;4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol Aguettant Ms Emma BQJCRHHNABKAKU-KBQPJGBKSA-N Oramorph D-(-)-Morphine Roxanol UD Dinamorf (-)-(etorphine) EINECS 200-320-2 (5alpha,6alpha)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol UNII-1M5VY6ITRT component BQJCRHHNABKAKU-KBQPJGBKSA-N (7R,7AS,12BS)-3-METHYL-2,3,4,4A,7,7A-HEXAHYDRO-1H-4,12-METHANO[1]BENZOFURO[3,2-E]ISOQUINOLINE-7,9-DIOL M-Eslon 4,5alpha-Epoxy-17-methyl-7-morphinen-3,6alpha-diol Morphia 4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol,sulfate(Morphinesulfate) Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl-, (5alpha,6alpha)- 6,11-Dimethyl-3-(3-methyl-but-2-enyl)-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol(Morphine) Morphine H.P 8053-16-5 Morphitec AN-23737 Mscontin, Oramorph CHEBI:17303 Rescudose DTXSID9023336 (1S,5R,13R,14S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol GTPL1627 SDZ202-250 ZINC3812983 1325730-46-8 methyl[?]diol 4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol ;sulphate salt(morphine) Morphina 4-methyl-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol (morphine) Morphine 0.1 mg/ml in Methanol 64-31-3 (sulfate (2:1) (salt) anhydrous) Morphine [BAN] 9H-9,9c-Iminoethanophenanthro(4,5-bcd)furan-3,5-diol, 4a,5,7a,8-tetrahydro-12-methyl- Moscontin BDBM50000092 NSC11441 CHEMBL70 Roxanol DepoDur Duramorph PF (4R,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol HSDB 2134 Statex SR l-Morphine 2-{4-[2,4-diamino-6-pteridinylmethyl(methyl)amino]phenylcarboxamido}pentanedioic acid(morphine) Morfina Dosa (TN) 4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol(morphine) Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5..alpha.,6.alpha.)- Morphine Extra-Forte 7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol(morphine) Morphinism AKOS015966554 MS/L C01516 Oramorph SR D08233 SCHEMBL2997 Dolcontin (-)-Morphine Epimorph (5alpha,6alpha)-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol UNII-76I7G6D29C (Morphine) M.O.S 4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol Morphin 4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diolMorphine 6-tert-Butyl-3-methyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocine Morphine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material 85201-37-2 Morphium Astramorph PF MSIR CHEMBL3978843 RMS DB00295 Dulcontin (1S,5R,13R,14S,17R)-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0;{1,13}.0;{5,17}.0;{7,18}]octadeca-7(18),8,10,15-tetraene-10,14-diol Hard stuff [ Show all ]
Inchi Key	BQJCRHHNABKAKU-KBQPJGBKSA-N
Inchi ID	InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1
PubChem CID	5288826
ChEMBL	CHEMBL70
IUPHAR	1627
BindingDB	50000092
DrugBank	DB00295
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Dose ratio	45.0 -	PMID1310115	ChEMBL
IC50	4.0 nM	PMID2887656	BindingDB,ChEMBL
IC50	8.5 nM	, Bioorg. Med. Chem. Lett., (1994) 4:21:2527	BindingDB,ChEMBL
IC50	29.0 nM	PMID25129170	BindingDB
IC50	29.3 nM	PMID25129170	ChEMBL
IC50	38.0 nM	PMID1851843	BindingDB,ChEMBL
IC50	57.3 nM	PMID7154002	BindingDB,ChEMBL
IC50	58.8 nM	PMID12166947	ChEMBL
IC50	59.0 nM	PMID12166947	BindingDB
IC50	70.0 nM	PMID2828622, PMID6276540	BindingDB,ChEMBL
IC50	71.6 nM	PMID1967312	ChEMBL
IC50	72.0 nM	PMID1967312	BindingDB
IC50	77.0 nM	PMID6313921	BindingDB,ChEMBL
IC50	311.0 nM	PMID15857143	BindingDB,ChEMBL
IC50	29300.0 nM	PMID18370374	BindingDB,ChEMBL
Ki	0.88 nM	PMID19027293, PMID11000010, PMID11425545	BindingDB
Ki	0.88 nM	PMID11425545, PMID11000010, PMID19027293	ChEMBL
Ki	1.0 nM	PMID11121615	BindingDB
Ki	1.1 nM	PMID21641798	BindingDB,ChEMBL
Ki	1.8 nM	PMID2832603	BindingDB,ChEMBL
Ki	1.98 nM	PMID21641219	BindingDB,ChEMBL
Ki	2.0 nM	PMID9686407	BindingDB
Ki	2.2 nM	PMID21481987	BindingDB,ChEMBL
Ki	2.5 nM	PMID16777416	BindingDB,ChEMBL
Ki	2.69 nM	PMID6248635	BindingDB
Ki	3.0 nM	PMID12930147	BindingDB,ChEMBL
Ki	3.3 nM	PMID1652025, PMID1846921, PMID1323679	BindingDB,ChEMBL
Ki	3.467 nM	PMID11960505	ChEMBL
Ki	3.5 nM	PMID23517479	ChEMBL
Ki	3.9 nM	PMID26411794	BindingDB,ChEMBL
Ki	6.5 nM	PMID9873603	BindingDB
Ki	6.51 nM	PMID9873603	ChEMBL
Ki	7.7 nM	PMID1967312	BindingDB
Ki	7.71 nM	PMID1967312	ChEMBL
Ki	38.0 nM	PMID7932535, PMID9873439	BindingDB,ChEMBL
Relative affinity	98.5 %	PMID11960505	ChEMBL
Relative Potency	1.0 -	PMID6313921	ChEMBL
Relative potency	1.0 -	PMID2887656	ChEMBL
Relative potency	100.0 -	PMID7154002	ChEMBL