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GPCR

NameProstaglandin E2 receptor EP1 subtype
SpeciesRattus norvegicus (Rat)
GenePtger1
SynonymEP1 prostanoid receptor
EP1 receptor
PGE receptor EP1 subtype
PGE2 receptor EP1 subtype
prostaglandin E receptor 1 (subtype EP1), 42kDa
[ Show all ]
DiseaseN/A for non-human GPCRs
Length405
Amino acid sequenceMSPYGLNLSLVDEATTCVTPRVPNTSVVLPTGGNGTSPALPIFSMTLGAVSNVLALALLAQVAGRLRRRRSTATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALALLAAMALAVALLPLVHVGHYELQYPGTWCFISLGPPGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRRSRRFRENAGPDDRRRWGSRGLRLASASSASSITSTTAALRSSRGGGSARRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELSLTKSAWEASSLRSSRHSGFSHL
UniProtP70597
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5068
IUPHAR340
DrugBankN/A

Ligand

NameCHEMBL467510
Molecular formulaC22H19ClNO3-
IUPAC name6-[2-[5-chloro-2-(2-methylpropoxy)phenyl]phenyl]pyridine-2-carboxylate
Molecular weight380.848
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP6.6
Synonyms6-(5''-chloro-2''-isobutoxy-biphenyl-2-yl)-pyridine-2-carboxylate Sodium
sodium 6-(5''-chloro-2''-isobutoxybiphenyl-2-yl)picolinate
BDBM50259548
Inchi KeyRVMVCPKCWWFOEL-UHFFFAOYSA-M
Inchi IDInChI=1S/C22H20ClNO3/c1-14(2)13-27-21-11-10-15(23)12-18(21)16-6-3-4-7-17(16)19-8-5-9-20(24-19)22(25)26/h3-12,14H,13H2,1-2H3,(H,25,26)/p-1
PubChem CID58974076
ChEMBLN/A
IUPHARN/A
BindingDB50259548
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC5012.6 nMPMID19036582BindingDB

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