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GPCR

NameHistamine H3 receptor
SpeciesMus musculus (Mouse)
GeneHrh3
SynonymGPCR97
H3 receptor
H3R
HH3R
DiseaseN/A for non-human GPCRs
Length445
Amino acid sequenceMERAPPDGLMNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVETGEAGLGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
UniProtP58406
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3263
IUPHAR264
DrugBankN/A

Ligand

NameFUB-349
Molecular formulaC13H16N2
IUPAC name5-(4-phenylbutyl)-1H-imidazole
Molecular weight200.285
Hydrogen bond acceptor1
Hydrogen bond donor1
XlogP3.2
SynonymsZINC29405823
184023-52-7
D0I4UU
FUB349
CHEMBL296450
[ Show all ]
Inchi KeyBQTXNCXSCSNHGA-UHFFFAOYSA-N
Inchi IDInChI=1S/C13H16N2/c1-2-6-12(7-3-1)8-4-5-9-13-10-14-11-15-13/h1-3,6-7,10-11H,4-5,8-9H2,(H,14,15)
PubChem CID9990388
ChEMBLCHEMBL296450
IUPHAR1259
BindingDB50071197
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
ED502.2 mg.kg-1PMID9873477ChEMBL
Ki15.8489 - 25.1189 nMPMID15341517IUPHAR

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