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GPCR

NameGalanin receptor type 3
SpeciesHomo sapiens (Human)
GeneGALR3
SynonymGAL3-R
Galnr3
GALR-3
GALR3
GAL3 receptor
DiseaseCognitive disorders
Length368
Amino acid sequenceMADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProtO60755
Protein Data BankN/A
GPCR-HGmod modelO60755
3D structure modelThis predicted structure model is from GPCR-EXP O60755.
BioLiPN/A
Therapeutic Target DatabaseT98494
ChEMBLCHEMBL2731
IUPHAR245
DrugBankN/A

Ligand

NameMLS001125299
Molecular formulaC21H25N5O
IUPAC nameN-[1-(2,3-dimethylphenyl)-4,5,6,7-tetrahydroindazol-4-yl]-1-ethylpyrazole-4-carboxamide
Molecular weight363.465
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP2.8
SynonymsMCULE-5548232073
N-[1-(2,3-dimethylphenyl)-4,5,6,7-tetrahydro-1H-indazol-4-yl]-1-ethyl-1H-pyrazole-4-carboxamide
CHEMBL1412747
N-[1-(2,3-dimethylphenyl)-4,5,6,7-tetrahydroindazol-4-yl]-1-ethylpyrazole-4-carboxamide
BDBM97151
[ Show all ]
Inchi KeyBQYFIAVBDDOJIP-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H25N5O/c1-4-25-13-16(11-22-25)21(27)24-18-8-6-10-20-17(18)12-23-26(20)19-9-5-7-14(2)15(19)3/h5,7,9,11-13,18H,4,6,8,10H2,1-3H3,(H,24,27)
PubChem CID24817872
ChEMBLCHEMBL1412747
IUPHARN/A
BindingDB97151
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50874.17 nM, PubChem BioAssay data setBindingDB,ChEMBL

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