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Name | Neuropeptide Y receptor type 2 |
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Species | Homo sapiens (Human) |
Gene | NPY2R |
Synonym | NPY2-R NPY-Y2 receptor neuropeptide Y receptor type 2 Y2 receptor |
Disease | Diabetes Metabolic disorders Obesity |
Length | 381 |
Amino acid sequence | MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV |
UniProt | P49146 |
Protein Data Bank | N/A |
GPCR-HGmod model | P49146 |
3D structure model | This predicted structure model is from GPCR-EXP P49146. |
BioLiP | N/A |
Therapeutic Target Database | T10670 |
ChEMBL | CHEMBL4018 |
IUPHAR | 306 |
DrugBank | BE0002419 |
Name | CHEMBL100162 |
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Molecular formula | C26H26N2OS2 |
IUPAC name | N-(2-benzylsulfanylphenyl)-N-[3-(methylamino)propyl]-1-benzothiophene-2-carboxamide |
Molecular weight | 446.627 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 6.2 |
Synonyms | BDBM50135648 Benzo[b]thiophene-2-carboxylic acid (2-benzylsulfanyl-phenyl)-(3-methylamino-propyl)-amide N-[3-(Methylamino)propyl]-N-[2-(benzylthio)phenyl]benzo[b]thiophene-2-carboxamide |
Inchi Key | ADUPCOZSFKRFSY-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C26H26N2OS2/c1-27-16-9-17-28(26(29)25-18-21-12-5-7-14-23(21)31-25)22-13-6-8-15-24(22)30-19-20-10-3-2-4-11-20/h2-8,10-15,18,27H,9,16-17,19H2,1H3 |
PubChem CID | 44329420 |
ChEMBL | CHEMBL100162 |
IUPHAR | N/A |
BindingDB | 50135648 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | <10000.0 nM | PMID14611849 | BindingDB,ChEMBL |
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