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GPCR

NameGlucagon receptor
SpeciesHomo sapiens (Human)
GeneGCGR
SynonymGL-R
GGR
GR
glucagon receptor
DiseaseDiabetes
Type 2 diabetes
Non-insulin dependent diabetes
Obesity; Diabetes
Type 1 diabetes
[ Show all ]
Length477
Amino acid sequenceMPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProtP47871
Protein Data Bank5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod modelP47871
3D structure modelThis structure is from PDB ID 5yqz.
BioLiPBL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target DatabaseT60182, T87875
ChEMBLCHEMBL1985
IUPHAR251
DrugBankN/A

Ligand

NameCHEMBL348555
Molecular formulaC24H22ClN3
IUPAC name2-[5-(4-chlorophenyl)-2-pyridin-4-yl-1H-pyrrol-3-yl]-N-propylaniline
Molecular weight387.911
Hydrogen bond acceptor2
Hydrogen bond donor2
XlogP6.1
SynonymsBDBM50075781
{2-[5-(4-Chloro-phenyl)-2-pyridin-4-yl-1H-pyrrol-3-yl]-phenyl}-propyl-amine
2-(4-Pyridinyl)-3-[2-(propylamino)phenyl]-5-(4-chlorophenyl)-1H-pyrrole
Inchi KeyBROAIVAKWDNNHD-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H22ClN3/c1-2-13-27-22-6-4-3-5-20(22)21-16-23(17-7-9-19(25)10-8-17)28-24(21)18-11-14-26-15-12-18/h3-12,14-16,27-28H,2,13H2,1H3
PubChem CID44373213
ChEMBLCHEMBL348555
IUPHARN/A
BindingDB50075781
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC5020.0 nMPMID10201821BindingDB,ChEMBL
IC50270.0 nMPMID10201821BindingDB,ChEMBL

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