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GPCR

NameAlpha-1A adrenergic receptor
SpeciesHomo sapiens (Human)
GeneADRA1A
Synonymalpha1a
ADRA1C
ADRA1L1
adrenergic alpha 1c receptor
adrenergic receptor alpha 1c
[ Show all ]
DiseaseUrinary incontinence
Benign prostatic hyperplasia
Cognitive disorders
Female sexual dysfunction
Glaucoma
[ Show all ]
Length466
Amino acid sequenceMVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
UniProtP35348
Protein Data BankN/A
GPCR-HGmod modelP35348
3D structure modelThis predicted structure model is from GPCR-EXP P35348.
BioLiPN/A
Therapeutic Target DatabaseT92609
ChEMBLCHEMBL229
IUPHAR22
DrugBankBE0000501

Ligand

Namenorepinephrine
Molecular formulaC8H11NO3
IUPAC name4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol
Molecular weight169.18
Hydrogen bond acceptor4
Hydrogen bond donor4
XlogP-1.2
Synonyms1,2-Benzenediol,4-(2-amino-1-hydroxyethyl)-
D0R2UN
21779-EP2298731A1
DSSTox_RID_77004
4-[(1R)-2-amino-1-hydroxy-ethyl]benzene-1,2-diol
[ Show all ]
Inchi KeySFLSHLFXELFNJZ-QMMMGPOBSA-N
Inchi IDInChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1
PubChem CID439260
ChEMBLCHEMBL1437
IUPHAR505
BindingDB50029051
DrugBankDB00368

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
N/A N/ADrugBank
Control response6.3 %PMID2982020ChEMBL
Control response6.7 %PMID2982020ChEMBL
Control response9.0 %PMID2982020ChEMBL
Control response9.3 %PMID2982020ChEMBL
Control response14.5 %PMID2982020ChEMBL
Control response45.3 %PMID2982020ChEMBL
EC509.1 nMPMID26125514BindingDB,ChEMBL
EC502187.76 nMPMID8831777ChEMBL
Emax117.0 %PMID8831777ChEMBL
Ki398.107 - 1584.89 nMPMID7651358, PMID10433504, PMID8564227IUPHAR
Ki1500.0 nMPMID2845082BindingDB,ChEMBL

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