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Name | Type-1B angiotensin II receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Agtr1b |
Synonym | Angiotensin II type-1B receptor AT1B AT3 |
Disease | N/A for non-human GPCRs |
Length | 359 |
Amino acid sequence | MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE |
UniProt | P29089 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL263 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL337025 |
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Molecular formula | C32H36N8O |
IUPAC name | 1-[2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazol-5-yl]-3-cyclohexylurea |
Molecular weight | 548.695 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 3 |
XlogP | 6.4 |
Synonyms | BIBR-179 SCHEMBL8396768 BDBM50043252 1-{2-Butyl-3-[2''-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazol-5-yl}-3-cyclohexyl-urea |
Inchi Key | BRTGYYMVGGPMTJ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C32H36N8O/c1-2-3-13-30-35-28-19-18-25(34-32(41)33-24-9-5-4-6-10-24)20-29(28)40(30)21-22-14-16-23(17-15-22)26-11-7-8-12-27(26)31-36-38-39-37-31/h7-8,11-12,14-20,24H,2-6,9-10,13,21H2,1H3,(H2,33,34,41)(H,36,37,38,39) |
PubChem CID | 10076199 |
ChEMBL | CHEMBL337025 |
IUPHAR | N/A |
BindingDB | 50043252 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 21.0 nM | PMID8258826 | BindingDB,ChEMBL |
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