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GPCR

NameAlpha-1B adrenergic receptor
SpeciesRattus norvegicus (Rat)
GeneAdra1b
Synonymadrenergic receptor
alpha 1B-adrenoceptor
alpha 1B-adrenoreceptor
adrenergic alpha 1B receptor
Alpha-1B adrenoceptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length515
Amino acid sequenceMNPDLDTGHNTSAPAHWGELKDDNFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRGGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGTQRTLPSASPSPGYLGRGTQPPVELCAFPEWKPGALLSLPEPPGRRGRLDSGPLFTFKLLGDPESPGTEGDTSNGGCDTTTDLANGQPGFKSNMPLAPGHF
UniProtP15823
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL315
IUPHAR23
DrugBankN/A

Ligand

NameVERAPAMIL
Molecular formulaC27H38N2O4
IUPAC name2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile
Molecular weight454.611
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP3.8
SynonymsTarka
KBio1_000399
KBio3_000466
Verapamilo [INN-Spanish]
Lekoptin
[ Show all ]
Inchi KeySGTNSNPWRIOYBX-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3
PubChem CID2520
ChEMBLCHEMBL6966
IUPHARN/A
BindingDB81939
DrugBankDB00661

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC501698.0 nMDrugMatrix in vitro pharmacology dataChEMBL
Ki940.0 nMDrugMatrix in vitro pharmacology dataChEMBL

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