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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(2) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R Dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61169
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL339
IUPHAR	215
DrugBank	N/A

Ligand

Name	CHEMBL458587
Molecular formula	C25H26N2O2
IUPAC name	(6aR)-2-[4-(dimethylamino)phenyl]-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol
Molecular weight	386.495
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	4.0
Synonyms	BDBM50251029 (R)-(-)-2-(4-N,N-Dimethylaminophenyl)-apomorphine dihydrochloride CHEMBL1186334
Inchi Key	BSBMMXOBOAVGQD-OAQYLSRUSA-N
Inchi ID	InChI=1S/C25H26N2O2/c1-26(2)19-7-4-15(5-8-19)18-12-17-10-11-27(3)21-14-16-6-9-22(28)25(29)24(16)20(13-18)23(17)21/h4-9,12-13,21,28-29H,10-11,14H2,1-3H3/t21-/m1/s1
PubChem CID	44567294
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50251029
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	484.0 nM	PMID18289859	BindingDB
Ki	242.0 nM	PMID18289859	BindingDB

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