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GPCR

NameProstaglandin E2 receptor EP2 subtype
SpeciesHomo sapiens (Human)
GenePTGER2
SynonymPGE receptor EP2 subtype
PGE2 receptor EP2 subtype
prostaglandin E receptor 2 (subtype EP2), 53kDa
Prostanoid EP2 receptor
Ptger-ep2
[ Show all ]
DiseaseOsteoporosis
Pulmonary arterial hypertension
Miscarriage
Medical abortion
Immune disorder
[ Show all ]
Length358
Amino acid sequenceMGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
UniProtP43116
Protein Data BankN/A
GPCR-HGmod modelP43116
3D structure modelThis predicted structure model is from GPCR-EXP P43116.
BioLiPN/A
Therapeutic Target DatabaseT38529
ChEMBLCHEMBL1881
IUPHAR341
DrugBankBE0000368

Ligand

NameCHEMBL260674
Molecular formulaC20H14ClFN2O5
IUPAC name2-[(3R)-5-chloro-1'-[(2-fluorophenyl)methyl]-2,2',5'-trioxospiro[indole-3,3'-pyrrolidine]-1-yl]acetic acid
Molecular weight416.789
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP1.8
Synonyms2-[(3R)-5-chloro-1''-[(2-fluorophenyl)methyl]-1,2-dihydrospiro[indole-3,3''-pyrrolidine]-2,2'',5''-trione]acetic acid
Spiro-indolinone analogue, (R)-58
ZINC14976624
BDBM21603
SCHEMBL2482377
Inchi KeySKLDVYDFQCXARY-HXUWFJFHSA-N
Inchi IDInChI=1S/C20H14ClFN2O5/c21-12-5-6-15-13(7-12)20(18(28)23(15)10-17(26)27)8-16(25)24(19(20)29)9-11-3-1-2-4-14(11)22/h1-7H,8-10H2,(H,26,27)/t20-/m1/s1
PubChem CID24776302
ChEMBLCHEMBL260674
IUPHARN/A
BindingDB21603
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<30000.0 nMPMID18318469ChEMBL

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