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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Muscarinic acetylcholine receptor M4
Species	Gallus gallus (Chicken)
Gene	CHRM4
Synonym	N/A
Disease	N/A for non-human GPCRs
Length	490
Amino acid sequence	MHNLSAQPWQAKMANLTYDNVTLSNRSEVAIQPPTNYKTVELVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGVFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWILSFILWAPAILFWQFIVGKRTVHERECYIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVRRHKPESRKERKGKSLSFFKAPPVKQNNNNSPKRAVEVKEEVRNGKVDDQPSAQTEATGQQEEKETSNESSTVSMTQTTKDKPTTEILPAGQGQSPAHPRVNPTSKWSKIKIVTKQTGTESVTAIEIVPAKAGASDHNSLSNSRPANVARKFASIARSQVRKKRQMAAREKKVTRTIFAILLAFILTWTPYNVMVLINTFCETCVPETVWSIGYWLCYVNSTINPACYALCNATFKKTFKHLLMCQYRNIGTAR
UniProt	P17200
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	N/A
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	cyclopentolate
Molecular formula	C17H25NO3
IUPAC name	2-(dimethylamino)ethyl 2-(1-hydroxycyclopentyl)-2-phenylacetate
Molecular weight	291.391
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	2.7
Synonyms	BCP21334 BPBio1_001288 CC-26105 Cyclogyl (Salt/Mix) Cyclopentylate DTXSID3048528 KBio2_006472 1-hydroxy-alpha-phenylcyclopentaneacetic acid 2-(dimethylamino)ethyl ester MolPort-005-935-560 2-dimethylaminoethyl 2-(1-hydroxycyclopentyl)-2-phenylacetate Prestwick1_001095 AC1Q67OG SPBio_003055 Bell Pentolate (TN) BSPBio_001170 Ciclopentolato D0B1EV GTPL7153 (+-)-cyclopentolate KBioSS_001336 2-(Dimethylamino)ethyl 1-hydroxy-alpha-phenylcyclopentaneacetate NCGC00018213-02 s114 alpha-(1-hydroxycyclopentyl)benzeneacetic acid 2-(dimethylamino)ethyl ester Spectrum4_000303 STL430452 beta-(Dimethylamino)ethyl (1-hydroxycyclopentyl)phenylacetate C06932 cyclo-pentolatum Cyclopentolatum Diopentolate KBio2_001336 .beta.-(Dimethylamino)ethyl (1-hydroxycyclopentyl)phenylacetate M-1318 2-Dimethylaminoethyl 1-hydroxy-.alpha.-phenylcyclopentaneacetate Ocu-Pentolate AC-15991 SKYSRIRYMSLOIN-UHFFFAOYSA-N AS-16057 BDBM82375 BRD-A77291778-003-05-5 CHEBI:4024 Cyclopentaneacetic acid, 1-hydroxy-.alpha.-phenyl-, 2-(dimethylamino)ethyl ester Cylate EINECS 208-136-4 KBio3_001317 2-(Dimethylamino)ethyl (1-hydroxycyclopentyl)(phenyl)acetate Mydrilate 2-phenyl-2-(1-hydroxycyclopentyl)ethanoic acid beta-(dimethylamino)ethyl ester Prestwick2_001095 ACM512152 Spectrum2_001122 Spectrum5_000793 Benzeneacetic acid, .alpha.-(1-hydroxycyclopentyl)-, 2-(dimethylamino)ethyl ester BSPBio_002097 Ciclopentolato [INN-Spanish] Cyclopentolate (INN) IDI1_000610 (+/-)-cyclopentolate L000802 2-(dimethylamino)ethyl 2-(1-hydroxycyclopentyl)-2-phenyl-acetate NINDS_000610 AB00053445 SBI-0051324.P003 AN-34337 beta-dimethylaminoethyl (1-hydroxycyclopentyl)phenylacetate CAS_512-15-2 Cyclogyl Cyclopentolatum [INN-Latin] DivK1c_000610 KBio2_003904 1-Hydroxy-.alpha.-phenylcyclopentaneacetic acid, 2-(dimethylamino)ethyl ester Minims Cyclopentolate 2-Dimethylaminoethyl 2-(1-hydroxycyclopentyl)-2-phenylacetat Prestwick0_001095 AC1L1EQK SPBio_000983 b-dimethylaminoethyl(1-hydroxycyclopentyl)phenylacetate Bell Pentolate BRD-A77291778-003-15-4 CHEMBL1201338 Cyclopentoiate D07759 FT-0624265 (+)-alpha-(1-Hydroxycyclopentyl)benzeneacetic acid 2-(dimethylamino)ethyl ester KBioGR_000886 2-(Dimethylamino)ethyl (1-hydroxycyclopentyl)(phenyl)acetate # Mydrilate (Salt/Mix) 512-15-2 Prestwick3_001095 AKOS015962137 Spectrum3_000369 Spectrum_000856 Benzeneacetic acid, alpha-(1-hydroxycyclopentyl)-, 2-(dimethylamino)ethyl ester C-23922 CTK8H5258 Cyclopentolate [INN:BAN] DB00979 KBio1_000610 (?)-alpha-(1-Hydroxycyclopentyl)benzeneacetic acid 2-(dimethylamino)ethyl ester LS-175236 2-(dimethylamino)ethyl 2-(1-hydroxycyclopentyl)-2-phenylacetate NSC_2905 AB00053445_12 SCHEMBL132500 API0009075 [ Show all ]
Inchi Key	SKYSRIRYMSLOIN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H25NO3/c1-18(2)12-13-21-16(19)15(14-8-4-3-5-9-14)17(20)10-6-7-11-17/h3-5,8-9,15,20H,6-7,10-13H2,1-2H3
PubChem CID	2905
ChEMBL	N/A
IUPHAR	N/A
BindingDB	82375
DrugBank	DB00979
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	4.68 nM	PMID2250662	BindingDB

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