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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	CHEMBL384848
Molecular formula	C23H24F3N3O
IUPAC name	N-[2-[methyl(propyl)amino]quinolin-6-yl]-3-[4-(trifluoromethyl)phenyl]propanamide
Molecular weight	415.46
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	5.5
Synonyms	ZINC36351778 BDBM50193677 N-(2-(methyl(propyl)amino)quinolin-6-yl)-3-(4-(trifluoromethyl)phenyl)propanamide SCHEMBL5873754
Inchi Key	BSJZAUQNVKQFNB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H24F3N3O/c1-3-14-29(2)21-12-7-17-15-19(10-11-20(17)28-21)27-22(30)13-6-16-4-8-18(9-5-16)23(24,25)26/h4-5,7-12,15H,3,6,13-14H2,1-2H3,(H,27,30)
PubChem CID	22018919
ChEMBL	CHEMBL384848
IUPHAR	N/A
BindingDB	50193677
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	10.0 nM	PMID16919456	BindingDB,ChEMBL

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