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GPCR

NameN-formyl peptide receptor 3
SpeciesHomo sapiens (Human)
GeneFPR3
SynonymFMLP-related receptor II
Lxa4r
LXA4-R
FPRL2
Fprl1
[ Show all ]
DiseaseN/A
Length353
Amino acid sequenceMETNFSIPLNETEEVLPEPAGHTVLWIFSLLVHGVTFVFGVLGNGLVIWVAGFRMTRTVNTICYLNLALADFSFSAILPFRMVSVAMREKWPFGSFLCKLVHVMIDINLFVSVYLITIIALDRCICVLHPAWAQNHRTMSLAKRVMTGLWIFTIVLTLPNFIFWTTISTTNGDTYCIFNFAFWGDTAVERLNVFITMAKVFLILHFIIGFSVPMSIITVCYGIIAAKIHRNHMIKSSRPLRVFAAVVASFFICWFPYELIGILMAVWLKEMLLNGKYKIILVLINPTSSLAFFNSCLNPILYVFMGRNFQERLIRSLPTSLERALTEVPDSAQTSNTDTTSASPPEETELQAM
UniProtP25089
Protein Data BankN/A
GPCR-HGmod modelP25089
3D structure modelThis predicted structure model is from GPCR-EXP P25089.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLN/A
IUPHAR224
DrugBankN/A

Ligand

NameCHEMBL2391263
Molecular formulaC24H20FN3O3S
IUPAC nameN-(4-fluorophenyl)-2-[5-[(3-methoxyphenyl)methyl]-6-oxo-3-thiophen-2-ylpyridazin-1-yl]acetamide
Molecular weight449.5
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP4.4
SynonymsBDBM50435929
Inchi KeySQNPGQUQGQNXHK-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H20FN3O3S/c1-31-20-5-2-4-16(13-20)12-17-14-21(22-6-3-11-32-22)27-28(24(17)30)15-23(29)26-19-9-7-18(25)8-10-19/h2-11,13-14H,12,15H2,1H3,(H,26,29)
PubChem CID71698623
ChEMBLCHEMBL2391263
IUPHARN/A
BindingDB50435929
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50<50000.0 nMPMID23685570BindingDB

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