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Name | Leukotriene B4 receptor 2 |
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Species | Homo sapiens (Human) |
Gene | LTB4R2 |
Synonym | NOP9 12-HHT receptor Seven transmembrane receptor BLTR2 LTB4-R2 LTB4-R 2 [ Show all ] |
Disease | Inflammatory bowel disease |
Length | 358 |
Amino acid sequence | MSVCYRPPGNETLLSWKTSRATGTAFLLLAALLGLPGNGFVVWSLAGWRPARGRPLAATLVLHLALADGAVLLLTPLFVAFLTRQAWPLGQAGCKAVYYVCALSMYASVLLTGLLSLQRCLAVTRPFLAPRLRSPALARRLLLAVWLAALLLAVPAAVYRHLWRDRVCQLCHPSPVHAAAHLSLETLTAFVLPFGLMLGCYSVTLARLRGARWGSGRHGARVGRLVSAIVLAFGLLWAPYHAVNLLQAVAALAPPEGALAKLGGAGQAARAGTTALAFFSSSVNPVLYVFTAGDLLPRAGPRFLTRLFEGSGEARGGGRSREGTMELRTTPQLKVVGQGRGNGDPGGGMEKDGPEWDL |
UniProt | Q9NPC1 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q9NPC1 |
3D structure model | This predicted structure model is from GPCR-EXP Q9NPC1. |
BioLiP | N/A |
Therapeutic Target Database | T30563 |
ChEMBL | CHEMBL3191 |
IUPHAR | 268 |
DrugBank | BE0003489 |
Name | CHEMBL1098560 |
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Molecular formula | C36H38O8S |
IUPAC name | 4-[3-[6-[3-(1,3-benzodioxol-5-yl)-5-thiophen-3-ylphenoxy]hexyl]-2-(2-carboxyethyl)phenoxy]butanoic acid |
Molecular weight | 630.752 |
Hydrogen bond acceptor | 9 |
Hydrogen bond donor | 2 |
XlogP | 8.0 |
Synonyms | RO5101576 4-{3-[6-(3-5-Benzo[1,3]dioxolyl-5-thiophen-3-ylphenoxy)hexyl]-2-(2-carboxyethyl)phenoxy}butyric Acid GTPL6158 SCHEMBL1689660 4-{3-[6-(3-benzo[1,3]dioxol-5-yl-5-thiophen-3-yl-phenoxy)-hexyl]-2-(2-carboxy-ethyl)-phenoxy}-butyric acid [ Show all ] |
Inchi Key | SRPFDFNVILUDAI-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C36H38O8S/c37-35(38)10-6-17-42-32-9-5-8-25(31(32)12-14-36(39)40)7-3-1-2-4-16-41-30-20-28(19-29(21-30)27-15-18-45-23-27)26-11-13-33-34(22-26)44-24-43-33/h5,8-9,11,13,15,18-23H,1-4,6-7,10,12,14,16-17,24H2,(H,37,38)(H,39,40) |
PubChem CID | 25192022 |
ChEMBL | CHEMBL1098560 |
IUPHAR | 6158 |
BindingDB | 50317626 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 164.0 nM | PMID20380377 | BindingDB,ChEMBL |
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