You can:
Name | Type-2 angiotensin II receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | AGTR2 |
Synonym | AT2 MRX88 Agtr2 angiotensin II receptor angiotensin II receptor, type 2 [ Show all ] |
Disease | Postherpetic neuralgia Hypertension |
Length | 363 |
Amino acid sequence | MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS |
UniProt | P50052 |
Protein Data Bank | 5xjm, 5unh, 5ung, 5unf |
GPCR-HGmod model | P50052 |
3D structure model | This structure is from PDB ID 5xjm. |
BioLiP | BL0419199, BL0375199,BL0375200, BL0375198, BL0375196,BL0375197 |
Therapeutic Target Database | T09909 |
ChEMBL | CHEMBL4607 |
IUPHAR | 35 |
DrugBank | BE0003426 |
Name | CHEMBL158557 |
---|---|
Molecular formula | C33H29NO7 |
IUPAC name | 5-[(4-carboxyphenyl)methoxy]-2-(2,2-diphenylacetyl)-6-methoxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid |
Molecular weight | 551.595 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 2 |
XlogP | 5.1 |
Synonyms | (RS)-5-(4-Carboxyphenylmethoxy)-2-(diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-3-isoquinolinecarboxylic acid ADYTVTJZRCKUAV-UHFFFAOYSA-N 5-(4-Carboxy-benzyloxy)-2-diphenylacetyl-6-methoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid BDBM50282409 (RS)-5-(4-Carboxyphenylmethoxy)-2-(diphenylacetyl) -1,2,3,4-tetrahydro-6-methoxy-3-isoquinolinecarboxylic acid [ Show all ] |
Inchi Key | ADYTVTJZRCKUAV-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C33H29NO7/c1-40-28-17-16-25-19-34(31(35)29(22-8-4-2-5-9-22)23-10-6-3-7-11-23)27(33(38)39)18-26(25)30(28)41-20-21-12-14-24(15-13-21)32(36)37/h2-17,27,29H,18-20H2,1H3,(H,36,37)(H,38,39) |
PubChem CID | 15296726 |
ChEMBL | CHEMBL158557 |
IUPHAR | N/A |
BindingDB | 50282409 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 750.0 nM | , Bioorg. Med. Chem. Lett., (1994) 4:1:57 | BindingDB,ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218