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GPCR

NameGastric inhibitory polypeptide receptor
SpeciesHomo sapiens (Human)
GeneGIPR
SynonymGIP-R
GIP receptor
Glucose-dependent insulinotropic polypeptide receptor
Gippr
DiseaseType 2 diabetes
Length466
Amino acid sequenceMTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC
UniProtP48546
Protein Data BankN/A
GPCR-HGmod modelP48546
3D structure modelThis predicted structure model is from GPCR-EXP P48546.
BioLiPN/A
Therapeutic Target DatabaseT41750
ChEMBLCHEMBL4383
IUPHAR248
DrugBankN/A

Ligand

Nameaminothiazole, 20
Molecular formulaC28H24F3N3O4S2
IUPAC name3-[[4-[[N-[4-(2-methoxyphenyl)-1,3-thiazol-2-yl]-4-(trifluoromethylsulfanyl)anilino]methyl]benzoyl]amino]propanoic acid
Molecular weight587.632
Hydrogen bond acceptor11
Hydrogen bond donor2
XlogP6.6
SynonymsCHEMBL472586
BDBM29123
SCHEMBL2647758
Inchi KeySWIHUIGRFYPTCP-UHFFFAOYSA-N
Inchi IDInChI=1S/C28H24F3N3O4S2/c1-38-24-5-3-2-4-22(24)23-17-39-27(33-23)34(20-10-12-21(13-11-20)40-28(29,30)31)16-18-6-8-19(9-7-18)26(37)32-15-14-25(35)36/h2-13,17H,14-16H2,1H3,(H,32,37)(H,35,36)
PubChem CID22496441
ChEMBLCHEMBL472586
IUPHARN/A
BindingDB29123
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC50<1000.0 nMPMID19385613BindingDB,ChEMBL

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